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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 to prevent or cure bacterial vaginosis among women with HIV
International Journal of Gynecology and Obstetrics, Volume 111, No. 3, Year 2010
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Description
Objective: To assess, among women with HIV, whether long-term oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 supplementation can prevent bacterial vaginosis (BV) and enhance the cure rate of metronidazole among those with BV. Methods: A randomized, double-blind, placebo-controlled trial conducted among 65 HIV-infected women with an aberrant microbiota (Nugent score 4-10) who were randomized to receive daily probiotics or placebo for 6 months. Those with BV (Nugent score 7-10) additionally received metronidazole for 10 days (400 mg twice daily). Results: We did not find an enhanced cure rate of BV among women with HIV treated with adjuvant probiotics to metronidazole treatment. Among women with an intermediate vaginal flora, probiotics tended to increase the probability of a normal vaginal flora (odds ratio 2.4; P = 0.1) and significantly increased the probability of a beneficial vaginal pH (odds ratio 3.8; P = 0.02) at follow-up. Conclusion: Supplementation of probiotic L. rhamnosus GR-1 and L. reuteri RC-14 did not enhance the cure of BV among women living with HIV, but may prevent the condition among this population. Trial registration: NCT00536848. © 2010 International Federation of Gynecology and Obstetrics All rights reserved.
Authors & Co-Authors
Hummelen, Ruben B.
Netherlands, Rotterdam
Erasmus Mc
Canada, London
Lawson Health Research Institute
Changalucha, John M.
Tanzania, Tanga
National Institute for Medical Research Tanga
Butamanya, Nicodemus L.
Tanzania
Sekou-toure Regional Hospital
Cook, Adrian
Tanzania
Kivulini Womens' Rights Organisation
Habbema, J. Dik F.
Netherlands, Rotterdam
Erasmus Mc
Reid, Gregor
Canada, London
Western University
Canada, London
Lawson Health Research Institute
Statistics
Citations: 89
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1016/j.ijgo.2010.07.008
ISSN:
00207292
Research Areas
Disability
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Participants Gender
Female