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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Type 2 diabetes-associated androgen alteration in patients with erectile dysfunction
International Journal of Andrology, Volume 31, No. 6, Year 2008
Notification
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Description
Our objective was to assess the pattern of type-2 diabetes-associated androgen alteration in patients with erectile dysfunction (ED). A total of 127 diabetic male patients with ED were enrolled in this study. Erectile function was assessed using the International Index of Erectile Function (IIEF). At the time of assessment, patients were also interviewed and assessed for socio-demographic and medical history that includes duration and severity of diabetes mellitus (DM). Patients underwent routine laboratory investigations, in addition to total testosterone (T), dehydroepiandrosterone sulphate (DHEA-S) and insulin assessment. The mean age ± SD was 53.8 ± 9.3 years. Of patients 25.2% (n = 32/127), 6.3% (n = 8/127) and 31.5% (n = 40/127) had low total T, low DHEA-S and hyperinsulinaemia respectively. There were significant association between the increase in age and body mass index and the presence of low T level. Of the patients 37.5% (n = 12/32) with low T level had glycosylated haemoglobin (HbA1c) >7% while, 22.1% (n = 21/95) of the patients with normal T level had HbA1c >7% (p < 0.05). There were significant associations between the number of patients with low level of total T or DHEA-S and poor control of DM. Patients with low T level were two times more likely (56.3%, n = 18/32) to have severe ED than patients with normal T level (27.4%, n = 26/95) (p < 0.01). There were significant differences between the mean levels of total T or DHEA-S and poor control of DM. No significant associations were detected between hyperinsulinaemia and the level of fasting blood sugar, duration of DM, metabolic control of DM or ED severity. Patients with low T level were three times as likely to have hyperinsulinaemia as those patients with normal T level (p < 0.05). The current study clearly demonstrated that there were significant associations between low level of total T or DHEA-S and poor control of DM. © 2007 The Authors.
Authors & Co-Authors
El-Sakka, Ahmed I.
Egypt, Ismailia
Faculty of Medicine
Saudi Arabia, Makkah
Al Noor Specialist Hospital
Sayed, Hisham M.
Egypt, Cairo
Faculty of Medicine
Tayeb, Khaled Al
Saudi Arabia, Makkah
Al Noor Specialist Hospital
Statistics
Citations: 34
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-2605.2007.00815.x
ISSN:
01056263
e-ISSN:
13652605
Research Areas
Noncommunicable Diseases
Sexual And Reproductive Health
Participants Gender
Male