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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: The IMHOTEP study
International Journal of Cardiology, Volume 333, Year 2021
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Description
Background: Heart failure (HF), the dominant form of cardiovascular disease in Africans, is mainly due to hypertension, rheumatic heart disease and cardiomyopathy. Cardiomyopathies pose a great challenge because of poor prognosis and high prevalence in low- and middle-income countries (LMICs). Little is known about the etiology and outcome of cardiomyopathy in Africa. Specifically, the role of myocarditis and the genetic causes of cardiomyopathy are largely unidentified in Africans. Method: The African Cardiomyopathy and Myocarditis Registry Program (the IMHOTEP study) is a pan-African multi-centre, hospital-based cohort study, designed with the primary aim of describing the clinical characteristics, genetic causes, prevalence, management and outcome of cardiomyopathy and myocarditis in children and adults. The secondary aim is to identify barriers to the implementation of evidence-based care and provide a platform for trials and other intervention studies to reduce morbidity and mortality in cardiomyopathy. The registry consists of a prospective cohort of newly diagnosed (i.e., incident) cases and a retrospective (i.e., prevalent) cohort of existing cases from participating centres. Patients with cardiomyopathy and myocarditis will be subjected to a standardized 3-stage diagnostic process. To date, 750 patients have been recruited into the multi-centre pilot phase of the study. Conclusion: The IMHOTEP study will provide comprehensive and novel data on clinical features, genetic causes, prevalence and outcome of African children and adults with all forms of cardiomyopathy and myocarditis in Africa. Based on these findings, appropriate strategies for management and prevention of the cardiomyopathies in LMICs are likely to emerge. © 2021 The Authors
Authors & Co-Authors
Kraus, Sarah M.
South Africa, Observatory
Groote Schuur Hospital
Shaboodien, G.
South Africa, Observatory
Groote Schuur Hospital
Francis, Veronica M.
South Africa, Observatory
Groote Schuur Hospital
Laing, Nakita
South Africa, Observatory
Groote Schuur Hospital
South Africa, Cape Town
University of Cape Town
Cirota, Jacqui
South Africa, Observatory
Groote Schuur Hospital
Chin, Ashley
South Africa, Observatory
Groote Schuur Hospital
Pandie, Shahiemah
South Africa, Observatory
Groote Schuur Hospital
Lawrenson, John Bernard
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
Tygerberg Hospital
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Comitis, George A.M.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Fourie, Barend
South Africa, Tygerberg
Tygerberg Hospital
Zühlke, Liesl Joanna
South Africa, Observatory
Groote Schuur Hospital
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Wonkam, Ambroise A.
South Africa, Observatory
Groote Schuur Hospital
South Africa, Cape Town
University of Cape Town
Wainwright, Helen Cecilia
South Africa, Cape Town
University of Cape Town
Damasceno, A. Antonio Moura
Mozambique, Maputo
Universidade Eduardo Mondlane
Mocumbi, Ana Olga H.
Mozambique, Maputo
Universidade Eduardo Mondlane
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Pepeta, Lungile
South Africa, Gqeberha
Nelson Mandela University
South Africa, Port Elizabeth
Dora Nginza Hospital
Moeketsi, Khulile P.
South Africa
Walter Sisulu University
South Africa, Mthatha
Nelson Mandela Academic Hospital
Thomas, Baby M.
South Africa
Walter Sisulu University
South Africa, Mthatha
Nelson Mandela Academic Hospital
Thomas, Kandathil M.
South Africa
Walter Sisulu University
South Africa, Mthatha
Nelson Mandela Academic Hospital
Makotoko, Makoali
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Brown, Stephen C.
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Ntsekhe, Mpiko
South Africa, Observatory
Groote Schuur Hospital
Sliwa, Karen S.
South Africa, Observatory
Groote Schuur Hospital
Badri, Motasim A.
South Africa, Observatory
Groote Schuur Hospital
Saudi Arabia, Riyadh
Abdulaziz University for Medical Sciences
Saudi Arabia, Riyadh
King Saud Bin Abdulaziz University for Health Sciences
Gumedze, Freedom N.
South Africa, Cape Town
University of Cape Town
Cordell, Heather Jane
United Kingdom, Newcastle
Newcastle University
Keavney, Bernard D.
United Kingdom, Manchester
The University of Manchester
Ferreira, Vanessa M.
United Kingdom, Oxford
University of Oxford
Mahmod, Masliza
United Kingdom, Oxford
University of Oxford
Cooper, Leslie T.
United States, Rochester
Mayo Clinic
Yacoub, Sir Magdi
United Kingdom, London
Harefield
Egypt, Aswan
Aswan Heart Centre
Neubauer, Stefan
United Kingdom, Oxford
University of Oxford
Watkins, Hugh C.
United Kingdom, Oxford
University of Oxford
Mayosi, Bongani M.
South Africa, Observatory
Groote Schuur Hospital
Ntusi, Ntobeko A.B.
South Africa, Observatory
Groote Schuur Hospital
Mwita, Julius Chacha
Botswana, Gaborone
University of Botswana
El-Guindy, Ahmed
Egypt, Aswan
Aswan Heart Centre
Kola, Tolno Sandy
Guinea, Conakry
Hôpital de L'amitié Sino Guinéenne de Kipé Conakry
Barasa, Felix Ayub
Kenya, Eldoret
Moi University
Ogah, Okechukwu Samuel
Nigeria, Ibadan
University College Hospital, Ibadan
Russell, James Baligeh Walter
Sierra Leone, Freetown
Connaught Hospital Sierra Leone
Pandie, Shaheen
South Africa, Observatory
Groote Schuur Hospital
Cupido, Blanche J.
South Africa, Observatory
Groote Schuur Hospital
de Decker, Rik
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Brink, Paul A.
South Africa, Tygerberg
Tygerberg Hospital
Heradien, Marshall J.
South Africa, Tygerberg
Tygerberg Hospital
Makubalo, Nomlindo
South Africa, Port Elizabeth
Dora Nginza Hospital
Nxele, Mahlubandile Fintan
South Africa, Port Elizabeth
Dora Nginza Hospital
Longo-Mbenza, Benjamin Ben I.Sasa
South Africa, Mthatha
Nelson Mandela Academic Hospital
Suliman, Ahmed Ali Ahmed
Sudan, Khartoum
Khartoum University
Ali, Sulafa Khalid Mohamed
Sudan, Khartoum
Sudan Heart Centre
Tibazarwa, Kemi B.
Tanzania, Dar es Salaam
Muhimbili National Hospital
Mondo, Charles Kiiza
Uganda, Kampala
St. Francis Hospital Uganda
Mungoma, Michael
Uganda, Kampala
Mulago Hospital
Gambahaya, Ellise Tapiwa
Zimbabwe, Harare
Andrew Fleming Hospital
Statistics
Citations: 4
Authors: 55
Affiliations: 31
Identifiers
Doi:
10.1016/j.ijcard.2021.02.026
ISSN:
01675273
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative