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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Implications of microfauna-host interactions for trypanosome transmission dynamics in Glossina fuscipes fuscipes in Uganda
Applied and Environmental Microbiology, Volume 78, No. 13, Year 2012
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Description
Tsetse flies (Diptera: Glossinidae) are vectors for African trypanosomes (Euglenozoa: kinetoplastida), protozoan parasites that cause African trypanosomiasis in humans (HAT) and nagana in livestock. In addition to trypanosomes, two symbiotic bacteria (Wigglesworthia glossinidia and Sodalis glossinidius) and two parasitic microbes, Wolbachia and a salivary gland hypertrophy virus (SGHV), have been described in tsetse. Here we determined the prevalence of and coinfection dynamics between Wolbachia, trypanosomes, and SGHV in Glossina fuscipes fuscipes in Uganda over a large geographical scale spanning the range of host genetic and spatial diversity. Using a multivariate analysis approach, we uncovered complex coinfection dynamics between the pathogens and statistically significant associations between host genetic groups and pathogen prevalence. It is important to note that these coinfection dynamics and associations with the host were not apparent by univariate analysis. These associations between host genotype and pathogen are particularly evident for Wolbachia and SGHV where host groups are inversely correlated for Wolbachia and SGHV prevalence. On the other hand, trypanosome infection prevalence is more complex and covaries with the presence of the other two pathogens, highlighting the importance of examining multiple pathogens simultaneously before making generalizations about infection and spatial patterns. It is imperative to note that these novel findings would have been missed if we had employed the standard univariate analysis used in previous studies. Our results are discussed in the context of disease epidemiology and vector control. © 2012, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3370491/bin/supp_78_13_4627__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3370491/bin/supp_78.13.4627_AEM-AEM00806-12-s01.pdf
Authors & Co-Authors
Alam, Uzma H.
United States, New Haven
Yale University
Hyseni, Chaz
United States, New Haven
Yale University
Symula, Rebecca E.
United States, New Haven
Yale University
Brelsfoard, Corey L.
United States, New Haven
Yale University
United States, Lexington
University of Kentucky College of Agriculture, Food and Environment
Wu, Yineng
United States, New Haven
Yale University
Kruglov, Oleg
United States, New Haven
Yale University
Wang, Jingwen
United States, New Haven
Yale University
Echodu, Richard
Uganda, Tororo
National Livestock Resources Research Institute
Alioni, Victor
Uganda, Tororo
National Livestock Resources Research Institute
Okedi, Loyce M.A.
Uganda, Tororo
National Livestock Resources Research Institute
Caccone, Adalgisa
United States, New Haven
Yale University
Aksoy, Serap
United States, New Haven
Yale University
Statistics
Citations: 47
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1128/AEM.00806-12
e-ISSN:
10985336
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Uganda