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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
Molecular Psychiatry, Volume 26, No. 9, Year 2021
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Description
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. © 2020, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8589647/bin/41380_2020_754_MOESM1_ESM.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC8589647/bin/41380_2020_754_MOESM2_ESM.docx
Authors & Co-Authors
Han, Laura K.M.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Dinga, Richard
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Nijmegen
Radboud Universiteit
Hahn, Tim
Germany, Munster
University of Münster
Ching, Christopher R.K.
United States, Los Angeles
University of Southern California
Eyler, Lisa Todd
United States, San Diego
Va San Diego Healthcare System
United States, La Jolla
University of California, San Diego
Aftanas, Lyubomir I.
Russian Federation, Novosibirsk
State Scientific-research Institute of Physiology and Basic Medicine
Russian Federation, Novosibirsk
Novosibirsk State University
Aghajani, Moji
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Aleman, André
Netherlands, Groningen
Rijksuniversiteit Groningen
Baune, Bernhard T.
Germany, Munster
University of Münster
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Berger, Klaus Ulrich
Germany, Munster
University of Münster
Brak, Ivan V.
Russian Federation, Novosibirsk
State Scientific-research Institute of Physiology and Basic Medicine
Russian Federation, Novosibirsk
Novosibirsk State University
Filho, Geraldo Busatto
Brazil, Sao Paulo
Universidade de São Paulo
Carballedo, Angela
Ireland, Dublin
Trinity College Dublin
Ireland, Dun Laoghaire
Mental Health Ireland
Connolly, Colm G.
United States, Tallahassee
Florida State University
Couvy-Duchesne, Baptiste
Australia, Brisbane
The University of Queensland
Cullen, Kathryn Regan
United States, Minneapolis
University of Minnesota Medical School
Dannlowski, Udo
Germany, Munster
University of Münster
Davey, Christopher G.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Dima, Danai
United Kingdom, London
University of London
United Kingdom, London
King's College London
Duran, Fabio Luis de Souza
Brazil, Sao Paulo
Universidade de São Paulo
Enneking, Verena
Germany, Munster
University of Münster
Filimonova, Elena A.
Russian Federation, Novosibirsk
State Scientific-research Institute of Physiology and Basic Medicine
Frenzel, Stefan
Germany, Greifswald
Universitätsmedizin Greifswald
Frodl, Thomas S.
Ireland, Dublin
Trinity College Dublin
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Fu, Cynthia H.Y.
United Kingdom, London
King's College London
United Kingdom, London
University of East London
Godlewska, Beata Renata
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Gotlib, Ian H.
United States, Palo Alto
Stanford University
Grabe, Hans Jörgen
Germany, Greifswald
Universitätsmedizin Greifswald
Germany, Greifswald
German Center for Neurodegenerative Diseases Dzne Site Rostock/greifswald
Groenewold, Nynke A.
Netherlands, Groningen
Rijksuniversiteit Groningen
South Africa, Cape Town
University of Cape Town
Grotegerd, Dominik
Germany, Munster
University of Münster
Gruber, Oliver
Germany, Heidelberg
Universität Heidelberg
Hall, Geoffrey B.C.
Canada, Hamilton
Mcmaster University
Harrison, Ben J.
Australia, Melbourne
Melbourne Health
Hatton, Sean N.
Australia, Sydney
The University of Sydney
United States, La Jolla
University of California, San Diego
Hermesdorf, Marco
Germany, Munster
University of Münster
Hickie, I. Bernard
Australia, Sydney
The University of Sydney
Ho, Tiffany C.
United States, Palo Alto
Stanford University
Hosten, Norbert
Germany, Greifswald
Universitätsmedizin Greifswald
Jansen, Andreas
Germany, Marburg
Philipps-universität Marburg
Kähler, Claas
Germany, Munster
University of Münster
Kircher, Tilo T.J.
Germany, Marburg
Philipps-universität Marburg
Klimes-Dougan, Bonnie
United States, Minneapolis
University of Minnesota Twin Cities
Krämer, Bernd K.
Germany, Heidelberg
Universität Heidelberg
Krug, Axel
Germany, Marburg
Philipps-universität Marburg
Germany, Bonn
Universität Bonn
Lagopoulos, Jim
Australia, Sydney
The University of Sydney
Australia, Sippy Downs
University of the Sunshine Coast
Leenings, Ramona
Germany, Munster
University of Münster
MacMaster, Frank P.
Canada, Calgary
University of Calgary
Canada, Calgary
Strategic Clinical Network for Addictions and Mental Health
MacQueen, Glenda M.
Canada, Calgary
University of Calgary
McIntosh, Andrew M.
United Kingdom, Edinburgh
The University of Edinburgh
McLellan, Quinn
Canada, Calgary
University of Calgary
Canada, Edmonton
University of Alberta
McMahon, Katie L.
Australia, Brisbane
Queensland University of Technology
Medland, Sarah E.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Mueller, Bryon A.
United States, Minneapolis
University of Minnesota Medical School
Mwangi, Benson I.
United States, Houston
University of Texas Health Science Center at Houston
Osipov, Evgeny A.
Russian Federation, Novosibirsk
Novosibirsk State University
Portella Moll, Maria J.
Spain, Barcelona
Institut de Recerca Sant Pau ir Sant Pau
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Pozzi, Elena
United States, Minneapolis
University of Minnesota Medical School
Australia, Melbourne
Melbourne Health
Reneman, Liesbeth
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Repple, Jonathan
Germany, Munster
University of Münster
Rosa, Pedro Gomes Penteado
Brazil, Sao Paulo
Universidade de São Paulo
Sacchet, Matthew D.
United States, Belmont
Mclean Hospital
Sämann, Philipp G.
Germany, Munich
Max Planck Institute of Psychiatry
Schnell, Knut
Germany, Gottingen
Universitätsmedizin Göttingen
Germany, Gottingen
Asklepios Fachklinikum Göttingen
Schrantee, Anouk G.M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Simulionyte, Egle
Canada, Hamilton
Mcmaster University
Soares, Jair C.
United States, Houston
University of Texas Health Science Center at Houston
Sommer, Jens
United States, Minneapolis
University of Minnesota Twin Cities
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
Steinsträter, Olaf
Germany, Greifswald
Universitätsmedizin Greifswald
Strike, Lachlan T.
Australia, Brisbane
The University of Queensland
Thomopoulos, Sophia I.
United States, Los Angeles
University of Southern California
van Tol, Marie José
Netherlands, Groningen
Rijksuniversiteit Groningen
Veer, Ilya Milos
Germany, Berlin
Freie Universität Berlin
Vermeiren, Robert R.J.M.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Leiden
Universiteit Leiden
Walter, Henrik
Germany, Berlin
Freie Universität Berlin
van der Wee, Nic J.A.
Netherlands, Leiden
Universiteit Leiden
Netherlands, Leiden
Leids Universitair Medisch Centrum
van der Werff, Steven J.A.
Netherlands, Leiden
Universiteit Leiden
Netherlands, Leiden
Leids Universitair Medisch Centrum
Whalley, Heather Clare
United Kingdom, Edinburgh
The University of Edinburgh
Winter, Nils Ralf
Germany, Munster
University of Münster
Wittfeld, Katharina
Germany, Greifswald
Universitätsmedizin Greifswald
Germany, Greifswald
German Center for Neurodegenerative Diseases Dzne Site Rostock/greifswald
Wright, Margaret J.
Australia, Brisbane
The University of Queensland
Wu, Mon Ju
United States, Houston
University of Texas Health Science Center at Houston
Völzke, Henry
Germany, Greifswald
Universitätsmedizin Greifswald
Yang, Tony T.
United States, San Francisco
University of California, San Francisco
Zannias, Vasileios
United Kingdom, Edinburgh
The University of Edinburgh
de Zubicaray, Greig I.
Australia, Brisbane
Queensland University of Technology
Zunta-Soares, Giovana B.
United States, Houston
University of Texas Health Science Center at Houston
Abé, Christoph
Sweden, Stockholm
Karolinska Institutet
Alda, Martin
Canada, Halifax
Dalhousie University, Faculty of Medicine
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Bøen, Erlend
Norway, Oslo
Oslo Universitetssykehus
Bonnín, Caterina del Mar
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Canales-Rodríguez, Erick Jorge
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Cannon, Dara M.
Ireland, Galway
University of Galway
Caseras, Xavier
United Kingdom, Cardiff
Mrc Centre for Neuropsychiatric Genetics and Genomics
Chaim-Avancini, Tiffany Moukbel
Brazil, Sao Paulo
Universidade de São Paulo
Elvsåshagen, Torbjorn
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Favre, Pauline
France, Gif-sur-yvette
Neurospin
France, Paris
Inserm
Foley, Sonya F.
United Kingdom, Cardiff
Cardiff University
Fullerton, Janice M.
Australia, Sydney
Neuroscience Research Australia
Australia, Sydney
Unsw Sydney
Goikolea, José M.
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Haarman, Bartholomeus C.M.
Netherlands, Groningen
Rijksuniversiteit Groningen
Haj́ek, Tomaś
Canada, Halifax
Dalhousie University, Faculty of Medicine
Henry, Chantal
France, Paris
Université Paris Cité
Houenou, Josselin
France, Gif-sur-yvette
Neurospin
France, Paris
Inserm
Howells, Fleur Margaret
South Africa, Cape Town
University of Cape Town
Ingvar, Martin C.
Sweden, Stockholm
Karolinska Institutet
Kuplicki, Rayus Tiberius
United States, Tulsa
Laureate Institute for Brain Research
Lafer, Beny
Brazil, Sao Paulo
Universidade de São Paulo
Landén, Mikaél
Sweden, Stockholm
Karolinska Institutet
Sweden, Gothenburg
Göteborgs Universitet
Machado-Vieira, Rodrigo
Brazil, Sao Paulo
Universidade de São Paulo
Malt, Ulrik Fredrik
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
McDonald, Colm D.
Ireland, Galway
University of Galway
Mitchell, Philip B.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Black Dog Institute
Nabulsi, Leila
Ireland, Galway
University of Galway
Otaduy, Maria Concepción García
Brazil, Sao Paulo
Universidade de São Paulo
Overs, Bronwyn J.
Australia, Sydney
Neuroscience Research Australia
Polosan, Mircea
France, Grenoble
Centre Hospitalier Universitaire de Grenoble
France, La Tronche
Grenoble Institut Des Neurosciences
Pomarol-Clotet, Edith
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Radua, Joaquim
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Rive, Maria M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Roberts, Gloria M.P.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Black Dog Institute
Salvador, Raymond
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Sarró, Salvador
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Satterthwaite, Theodore Daniel
United States, Philadelphia
University of Pennsylvania
Savitz, Jonathan
United States, Tulsa
Laureate Institute for Brain Research
United States, Tulsa
The University of Tulsa
Schene, Aart Herman
Netherlands, Nijmegen
Radboud Universiteit
Netherlands, Nijmegen
Radboud University Medical Center
Schofield, Peter R.
Australia, Sydney
Neuroscience Research Australia
Australia, Sydney
Unsw Sydney
Serpa, Mauricio Henriques
Brazil, Sao Paulo
Universidade de São Paulo
Sim, Kang
Singapore, Singapore City
Singapore Institute of Mental Health
Singapore, Singapore City
National University of Singapore
Soeiro-De-souza, M. G.
Brazil, Sao Paulo
Universidade de São Paulo
Temmingh, Henk S.
Germany, Heidelberg
Universität Heidelberg
South Africa, Cape Town
Valkenberg Psychiatric Hospital
Uhlmann, Anne
South Africa, Cape Town
University of Cape Town
Vieta, Eduard
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Wolf, Daniel H.
United States, Philadelphia
University of Pennsylvania
Zanetti, M. V.
Brazil, Sao Paulo
Universidade de São Paulo
Brazil, Bela Vista
Hospital Sirio-libanês
Jahanshad, Neda
United States, Los Angeles
University of Southern California
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Veltman, Dick J.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Penninx, Brenda W. J. H.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Marquand, Andre F.
Netherlands, Nijmegen
Radboud Universiteit
Netherlands, Nijmegen
Radboud University Medical Center
Cole, James H.
United Kingdom, London
King's College London
United Kingdom, London
University College London
Schmaal, Lianne
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Statistics
Citations: 173
Authors: 143
Affiliations: 82
Identifiers
Doi:
10.1038/s41380-020-0754-0
ISSN:
13594184
Study Design
Cohort Study
Participants Gender
Male
Female