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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
An evaluation of urine-CCA strip test and fingerprick blood SEA-ELISA for detection of urinary schistosomiasis in schoolchildren in Zanzibar
Acta Tropica, Volume 111, No. 1, Year 2009
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Description
To develop better monitoring protocols for detection of urinary schistosomiasis during ongoing control interventions, two commercially available diagnostic tests - the urine-circulating cathodic antigen (CCA) strip and the soluble egg antigen enzyme-linked immunosorbent assay (SEA-ELISA) - were evaluated for detection of Schistosoma haematobium infections in 150 schoolchildren from Zanzibar. The children originated from five primary schools representative of different levels of disease endemicity across the island; using standard urine filtration assessment with microscopy, mean prevalence of S. haematobium was 30.7% (95% confidence interval (CI) = 23.4-38.7%) and a total of 35.3% (95% CI = 27.7-43.5%) and 8.0% (95% CI = 4.2-13.6%) children presented with micro- and macro-haematuria, respectively. Diagnostic scores of the urine-CCA strip were not satisfactory, a very poor sensitivity of 9% (95% CI = 2-21%) was observed, precluding any further consideration. By contrast, the performance of the SEA-ELISA using sera from fingerprick blood was good; a sensitivity of 89% (95% CI = 76-96%), a specificity of 70% (95% CI = 60-79%), a positive predictive value of 57% (95% CI = 45-69%) and a negative predictive value of 90% (95% CI = 86-98%) were found. At the unit of the school, a positive linear association between prevalence inferred from parasitological examination and SEA-ELISA methods was found. The SEA-ELISA holds promise as a complementary field-based method for monitoring infection dynamics in schoolchildren over and above standard parasitological methods. Crown Copyright © 2009.
Authors & Co-Authors
Russell Stothard, John Russell
United Kingdom, London
The Natural History Museum, London
Sousa-Figueiredo, José Carlos
United Kingdom, London
The Natural History Museum, London
Standley, Claire J.
United Kingdom, London
The Natural History Museum, London
van Dam, Govert Jan
Netherlands, Leiden
Leids Universitair Medisch Centrum
Knopp, Stefanie
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Utzinger, Jürg
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Ameri, Haji
Tanzania, Mkokotoni
Ministry of Health Zanzibar
Khamis, Alipo Naim
Tanzania, Mkokotoni
Ministry of Health Zanzibar
Khamis, Iddi Simba
Tanzania, Mkokotoni
Ministry of Health Zanzibar
Deelder, André Martien
Netherlands, Leiden
Leids Universitair Medisch Centrum
Mohammed, Khalfan Abdallah
Tanzania, Mkokotoni
Ministry of Health Zanzibar
Rollinson, D.
United Kingdom, London
The Natural History Museum, London
Statistics
Citations: 106
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/j.actatropica.2009.02.009
ISSN:
0001706X
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study