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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Reproducibility of bone mineral density measurements using dual X-ray absorptiometry in daily clinical practice
Osteoporosis International, Volume 16, No. 12, Year 2005
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Description
Bone mineral density (BMD) measurements are frequently performed repeatedly for each patient. Subsequent BMD measurements allow reproducibility to be assessed. Previous studies have suggested that reproducibility may be influenced by age and clinical status. The purpose of the study was to examine the reproducibility of BMD by dual energy X-ray absorptiometry (DXA) and to investigate the practical value of different measures of reproducibility in three distinct groups of subjects: healthy young volunteers, postmenopausal women and patients with chronic rheumatic diseases. Two hundred twenty-two subjects underwent two subsequent BMD measurements of the spine and hip. There were 60 young healthy subjects, 102 postmenopausal women and 60 patients with chronic rheumatic diseases (33 rheumatoid arthritis, 10 ankylosing spondylitis and 10 other systemic diseases). Forty-five patients (75%) among the third group were receiving corticosteroids. Reproducibility was expressed as the smallest detectable difference (SDD), coefficient of variation (CV), least significant change (LSC) and intraclass correlation coefficient (ICC). Sources of variation were investigated by linear regression analysis. The median interval between measurements was 0 days (range 0-7). The mean difference (SD) between the measurements (g/cm2) was -0.0001 (±0.003) and -0.0004 (±0.002) at L1-L4 and the total hip, respectively. At L1-L4 and the total hip, SDD (g/cm2) was ±0.04 and ±0.02, CV (%) was 2.02 and 1.29, and LSC (%) 5.60 and 3.56, respectively. The ICC at the spine and hip was 0.99 and 0.99, respectively. Only a minimal difference existed between the groups. Reproducibility in the three groups studied was good. In a repeated DXA scan, a BMD change, the least significant change (LSC) or the SDD should be regarded as significant. Use of the SDD is preferable to use of the CV and LSC because of its independence from BMD and its expression in absolute units. Expressed as SDD, a BMD change of at least ±0.04 g/cm2 at L1-L4 and ±0.02 g/cm2 at the total hip should be considered significant. This reproducibility seems independent from age and clinical status and improved in the hips by measuring the dual femur. © International Osteoporosis Foundation and National Osteoporosis Foundation 2005.
Authors & Co-Authors
El Maghraoui, Abdellah
Morocco, Agdal Rabat
Military Hospital Mohammed V
Do Santos Zounon, A. A.
Morocco, Agdal Rabat
Military Hospital Mohammed V
Jroundi, Imane
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Nouijai, Abderrazak
Morocco, Agdal Rabat
Military Hospital Mohammed V
Ghazi, Mirieme
Morocco, Agdal Rabat
Military Hospital Mohammed V
Achemlal, Lahcen
Morocco, Agdal Rabat
Military Hospital Mohammed V
Bezza, Ahmed
Morocco, Agdal Rabat
Military Hospital Mohammed V
Tazi, Mohammed Adnane
Morocco, Agdal Rabat
Ministry of Health, Morocco
Abouqal, Redouane
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Statistics
Citations: 90
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1007/s00198-005-1916-2
ISSN:
0937941X
e-ISSN:
14332965
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Approach
Quantitative
Participants Gender
Female