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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sulfur amino acids in methionine-restricted rats: Hyperhomocysteinemia
Nutrition, Volume 26, No. 11-12, Year 2010
Notification
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Description
Objective: Dietary methionine restriction in Fischer-344 rats favorably influences visceral fat mass, insulin sensitivity, metabolic parameters, and longevity. However, little is known about the effects of methionine restriction on serum methionine and its downstream sulfur amino acids. We investigated the serum sulfur amino acid profile of male Fischer-344 rats fed a methionine-restricted diet for 3 mo. Methods and results: Using tandem mass spectrometry, we observed marked reduction in serum concentrations of methionine, cystathionine, cysteine, and taurine in methionine-restricted rats compared with control (P< 0.001) and a 2.5-fold elevation of homocysteine (P< 0.001). Conclusion: This suggests that homocysteine trans-sulfuration may be inhibited by methionine restriction, and that some of the effects of methionine restriction may be mediated by changes in sulfur amino acids downstream of methionine. © 2010.
Authors & Co-Authors
Elshorbagy, Amany K.
United Kingdom, Oxford
University of Oxford
Valdivia-Garcia, Maria
United Kingdom, Oxford
University of Oxford
Refsum, Helga M.
United Kingdom, Oxford
University of Oxford
Norway, Oslo
Universitetet I Oslo
Smith, A. David
United Kingdom, Oxford
University of Oxford
Mattocks, Dwight A.L.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Perrone, Carmen E.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Statistics
Citations: 81
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.nut.2009.09.017
ISSN:
08999007
Research Areas
Noncommunicable Diseases
Participants Gender
Male