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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
engineering
A novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties
Journal of Biomedical Materials Research - Part B Applied Biomaterials, Volume 108, No. 1, Year 2020
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Description
The aim of the current study was to synthesize a fast-setting ion-doped calcium silicate bioceramic by the sol–gel method and to characterize its in vitro apatite-forming ability and cell viability. Calcium silicate (CS), doped calcium silicate with zinc and magnesium, with Ca/Zn molar ratios of 6.7:1 (DCS1), and 4.5:1 (DCS2), were synthesized by the sol–gel method. Matreva white MTA (WMTA, Matreva, CA, Egypt) was used as a control. The synthesized powders were characterized by x-ray diffraction. Setting time was measured using the Gilmore needle indentation technique. The in vitro apatite-forming ability of the materials was evaluated by scanning electron microscope and energy dispersive X-ray. NIH3T3-E1 cells viability was tested using MTT assay. The ion release of Ca, Si, Zn, and Mg was measured using inductive coupled plasma-optical emission spectroscopy (ICP-OES). One-way ANOVA was used to analyze setting time results. The Tukey's HSD post hoc test was used to establish significance (p < 0.001). For nonparametric data, the Kruskal–Wallis H test with Dunn's correction for post hoc comparison was used (p < 0.05). CS, DCS1, and DCS2 showed a significant decrease in setting time 33 ± 1.63 min, 28 ± 1.63 min, and 41.75 ± 2.87 min, respectively, compared to WMTA 91 ± 3.16 min (p < 0.001). DCS1 showed the highest apatite-forming ability and cell viability compared to the other groups. Ca and Si ions release decreased in both DCS1 and DCS2. The physical and biological properties of CS can be successfully improved by the sol–gel synthesis and ions doping. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:56–66, 2020.
Authors & Co-Authors
Abdalla, Mohamed Mahmoud
Hong Kong, Hong Kong
The University of Hong Kong
Egypt, Cairo
Faculty of Dentistry
Kei Lung, Christie Ying
Hong Kong, Hong Kong
The University of Hong Kong
Neelakantan, Prasanna
Hong Kong, Hong Kong
The University of Hong Kong
Matinlinna, Jukka Pekka
Hong Kong, Hong Kong
The University of Hong Kong
Statistics
Citations: 30
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/jbm.b.34365
ISSN:
15524973
e-ISSN:
15524981
Research Areas
Environmental
Study Design
Exploratory Study
Study Approach
Qualitative
Study Locations
Egypt