Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants
Psychological Medicine, Volume 53, No. 14, Year 2023
Notification
URL copied to clipboard!
Description
Background: Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact. Methods: We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations. Results: BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI. Conclusions: We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain. © The Author(s), 2023.
Authors & Co-Authors
McWhinney, Sean R.
Canada, Halifax
Dalhousie University
Abé, Christoph
Sweden, Stockholm
Karolinska Institutet
Alda, Martin
Canada, Halifax
Dalhousie University
Benedetti, Francesco
Italy, Milan
Università Vita-salute San Raffaele
Italy, Milan
Irccs Ospedale San Raffaele
Bøen, Erlend
Norway, Oslo
Oslo Universitetssykehus
del Mar Bonnín, Caterina
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Borgers, Tiana
Germany, Munster
University of Münster
Brosch, Katharina
Germany, Marburg
Philipps-universität Marburg
Canales-Rodríguez, Erick Jorge
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Cannon, Dara M.
Ireland, Galway
University of Galway
Dannlowski, Udo
Germany, Munster
University of Münster
Diáz-Zuluaga, Ana María
Colombia, Medellin
Universidad de Antioquia
Dietze, Lorielle M.F.
Canada, Halifax
Dalhousie University
Elvsåshagen, Torbjorn
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Eyler, Lisa Todd
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Fullerton, Janice M.
Australia, Sydney
Neuroscience Research Australia
Australia, Sydney
Unsw Sydney
Goikolea, José M.
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Goltermann, Janik
Germany, Munster
University of Münster
Grotegerd, Dominik
Germany, Munster
University of Münster
Hahn, Tim
Germany, Munster
University of Münster
Howells, Fleur Margaret
South Africa, Cape Town
University of Cape Town
Ingvar, Martin C.
Sweden, Stockholm
Karolinska Institutet
Jahanshad, Neda
United States, Los Angeles
University of Southern California
Kircher, Tilo T.J.
Germany, Marburg
Philipps-universität Marburg
Krug, Axel
Germany, Marburg
Philipps-universität Marburg
Germany, Bonn
Universitätsklinikum Bonn
Kuplicki, Rayus Tiberius
United States, Tulsa
Laureate Institute for Brain Research
Landén, Mikaél
Sweden, Gothenburg
Göteborgs Universitet
Sweden, Stockholm
Karolinska Institutet
Lemke, Hannah
Germany, Munster
University of Münster
Liberg, Benny
Sweden, Stockholm
Karolinska Institutet
López-Jaramillo, Carlos Alberto
Colombia, Medellin
Universidad de Antioquia
Malt, Ulrik Fredrik
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Martyn, Fiona M.
Ireland, Galway
University of Galway
Mazza, Elena Beatrice
Italy, Milan
Università Vita-salute San Raffaele
Italy, Milan
Irccs Ospedale San Raffaele
McDonald, Colm D.
Ireland, Galway
University of Galway
McPhilemy, Genevieve
Ireland, Galway
University of Galway
Meier, Sandra Melanie
Canada, Halifax
Dalhousie University
Meinert, Susanne L.
Germany, Munster
University of Münster
Meller, Tina
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Melloni, Elisa Maria Teresa
Italy, Milan
Università Vita-salute San Raffaele
Italy, Milan
Irccs Ospedale San Raffaele
Mitchell, Philip B.
Australia, Sydney
Unsw Sydney
Nabulsi, Leila
Ireland, Galway
University of Galway
Nenadić, Igor
Germany, Marburg
Philipps-universität Marburg
Opel, Nils
Germany, Munster
University of Münster
Germany, Jena
Friedrich-schiller-universität Jena
Ophoff, Roel A.
United States, Los Angeles
Jane & Terry Semel Institute for Neuroscience & Human Behavior
Netherlands, Rotterdam
Erasmus Mc
Overs, Bronwyn J.
Australia, Sydney
Neuroscience Research Australia
Pfarr, Julia Katharina
Germany, Marburg
Philipps-universität Marburg
Pineda-Zapata, Julián Alberto
Colombia, Medellin
Instituto de Alta Tecnología Médica
Pomarol-Clotet, Edith
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Radua, Joaquim
Sweden, Stockholm
Karolinska Institutet
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
United Kingdom, London
King's College London
Repple, Jonathan
Germany, Munster
University of Münster
Germany, Frankfurt am Main
Goethe-universität Frankfurt am Main
Richter, Maike Frederike
Germany, Munster
University of Münster
Ringwald, Kai Gustav
Germany, Marburg
Philipps-universität Marburg
Roberts, Gloria M.P.
Australia, Sydney
Unsw Sydney
Ross, Alex J.
Canada, Halifax
Dalhousie University
Salvador, Raymond
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Savitz, Jonathan
Germany, Bonn
Universitätsklinikum Bonn
United States, Tulsa
The University of Tulsa
Schmitt, Simon
Germany, Marburg
Philipps-universität Marburg
Schofield, Peter R.
Australia, Sydney
Neuroscience Research Australia
Australia, Sydney
Unsw Sydney
Sim, Kang
Singapore, Singapore City
Singapore Institute of Mental Health
Singapore, Singapore City
National University of Singapore
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Stein, Frederike
Germany, Marburg
Philipps-universität Marburg
Temmingh, Henk S.
South Africa, Cape Town
University of Cape Town
Thiel, Katharina
Germany, Munster
University of Münster
Thomopoulos, Sophia I.
United States, Los Angeles
University of Southern California
van Haren, Neeltje E.M.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Utrecht
Universiteit Utrecht
Vargas-Upeguí, Cristian David
Colombia, Medellin
Universidad de Antioquia
Vieta, Eduard
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Vreeker, Annabel
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Utrecht
Universiteit Utrecht
Netherlands, Rotterdam
Erasmus Universiteit Rotterdam
Waltemate, Lena
Germany, Munster
University of Münster
Yatham, Lakshmi N.
Canada, Vancouver
The University of British Columbia
Ching, Christopher R.K.
United States, Los Angeles
University of Southern California
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Haj́ek, Tomaś
Canada, Halifax
Dalhousie University
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Statistics
Citations: 2
Authors: 74
Affiliations: 37
Identifiers
Doi:
10.1017/S0033291723000223
ISSN:
00332917
Research Areas
Mental Health
Noncommunicable Diseases