Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Labial salivary gland biopsy is a reliable test for the diagnosis of primary and secondary amyloidosis. a prospective clinical and immunohistologic study in 59 patients
Arthritis & Rheumatism, Volume 36, No. 5, Year 1993
Notification
URL copied to clipboard!
Description
Objective. Reports of the detection of amyloidosis by labial salivary gland (LSG) biopsy have been mostly anecdotal. The aim of this study was to assess the value of this method in the diagnosis of amyloidosis. Methods. LSG biopsy tissues were studied with a combination method using Congo red stain and immunohistologic characterization using an antibody directed against the serum amyloid P (SAP) component. Electron microscopy was performed in all cases. In a prospective study, we evaluated 30 patients with biopsy‐proven AA or AL amyloidosis. We compared these patients with a control group of 29 age‐matched patients without clinical or biologic evidence of amyloid disease (14 had rheumatoid arthritis and 15 had plasma cell dyscrasia). Results. In 26 of the 30 patients with known systemic amyloidosis, amyloid deposits were identified on LSG biopsy (sensitivity of 86%). In 1 of the remaining patients, amyloid deposits were identified on LSG biopsy and systemic amyloidosis was confirmed by abdominal fat biopsy and 123I‐labeled SAP scintigraphy. Conclusion. This study emphasizes the high sensitivity of LSG biopsy in the diagnosis of amyloidosis, even in the absence of oral symptoms. Copyright © 1993 American College of Rheumatology
Authors & Co-Authors
Hachulla, Éric
France, Lille
Chu Lille
Janin, Anne
France, Lille
Chu Lille
Flipo, Réné Marc
France, Lille
Chu Lille
Saile, Rachid
France, Lille
Chu Lille
Façon, Thierry
France, Lille
Chu Lille
Vanhille, Phillippe
France, Lille
Chu Lille
Hatron, Pierre Yves
France, Lille
Chu Lille
Statistics
Citations: 83
Authors: 7
Affiliations: 1
Identifiers
Doi:
10.1002/art.1780360518
ISSN:
00043591
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cohort Study
Study Locations
Congo