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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Towards Rational Use of Antibiotics for Suspected Secondary Infections in Buruli Ulcer Patients
PLoS Neglected Tropical Diseases, Volume 7, No. 1, Article e2010, Year 2013
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Description
Background: The emerging disease Buruli ulcer is treated with streptomycin and rifampicin and surgery if necessary. Frequently other antibiotics are used during treatment. Methods/Principal Findings: Information on prescribing behavior of antibiotics for suspected secondary infections and for prophylactic use was collected retrospectively. Of 185 patients that started treatment for Buruli ulcer in different centers in Ghana and Bénin 51 were admitted. Forty of these 51 admitted patients (78%) received at least one course of antibiotics other than streptomycin and rifampicin during their hospital stay. The median number (IQR) of antibiotic courses for admitted patients was 2 (1, 5). Only twelve patients received antibiotics for a suspected secondary infection, all other courses were prescribed as prophylaxis of secondary infections extended till 10 days on average after excision, debridement or skin grafting. Antibiotic regimens varied considerably per indication. In another group of BU patients in two centers in Bénin, superficial wound cultures were performed. These cultures from superficial swabs represented bacteria to be expected from a chronic wound, but 13 of the 34 (38%) S. aureus were MRSA. Conclusions/Significance: A guide for rational antibiotic treatment for suspected secondary infections or prophylaxis is needed. Adherence to the guideline proposed in this article may reduce and tailor antibiotic use other than streptomycin and rifampicin in Buruli ulcer patients. It may save costs, reduce toxicity and limit development of further antimicrobial resistance. This topic should be included in general protocols on the management of Buruli ulcer. © 2013 Barogui et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3554522/bin/pntd.0002010.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3554522/bin/pntd.0002010.s002.doc
Authors & Co-Authors
Barogui, Yves Thierry
Benin, Cotonou
Ministère de la Santé
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Klis, Sandor Adrian
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Bankolé, Honoré Sourou
Benin, Cotonou
University of Abomey-calavi
Sopoh, Ghislain Emmanuel
Benin, Cotonou
Ministère de la Santé
Mamo, Solomon
Ghana, Agogo
Agogo Presbyterian Hospital
Baba-Moussa, Lamine Saïd
Benin, Cotonou
University of Abomey-calavi
Manson, Willem L.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Johnson, Roch Christian
Unknown Affiliation
Van Derwerf, Tjip S.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Stienstra, Ymkje
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Statistics
Citations: 29
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pntd.0002010
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Health System And Policy
Study Locations
Ghana