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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
One year survey of human rotavirus strains suggests the emergence of genotype G12 in Cameroon
Journal of Medical Virology, Volume 85, No. 8, Year 2013
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Description
In this study the emergence of rotavirus A genotype G12 in children <5 years of age is reported from Cameroon during 2010/2011. A total of 135 human stool samples were P and G genotyped by reverse transcriptase PCR. Six different rotavirus VP7 genotypes were detected, including G1, G2, G3, G8, G9, and G12 in combinations with P[4], P[6] and P[8] VP4 genotypes. Genotype G12 predominated in combination with P[8] (54.1%) and P[6] (10.4%) genotypes followed by G1P[6] (8.2%), G3P[6] (6.7%), G2P[4] (5.9%), G8P[6] (3.7%), G2P[6] (0.7%), G3P[8] (0.7%), and G9P[8] (0.7%). Genotype P[6] strains in combination with various G-types represented a substantial proportion (N = 44, 32.6%) of the genotyped strains. Partially typed strains included G12P[NT] (2.2%); G3P[NT] (0.7%); G(NT)P[6] (1.5%); and G(NT)P[8] (0.7%). Mixed infections were found in five specimens (3.7%) in several combinations including G1+G12P[6], G2+G3P[6]+P[8], G3+G8P[6], G3+G12P[6]+P[8], and G12P[6]+P[8]. The approximately 10% relative frequency of G12P[6] strains detected in this study suggests that this strain is emerging in Cameroon and should be monitored carefully as rotavirus vaccine is implemented in this country, as it shares neither G- nor P-type specificity with strains in the RotaTeq® and Rotarix® vaccines. These findings are consistent with other recent reports of the global spread and increasing epidemiologic importance of G12 and P[6] strains. © 2013 Wiley Periodicals, Inc.
Authors & Co-Authors
Ndze, Valentine Ngum
Cameroon, Yaounde
Université de Yaoundé I
Papp, Hajnalka
Hungary, Budapest
Magyar Tudomanyos Akademia
Achidi, Eric Akum
Cameroon, Buea
University of Buea
Gonsu, Kamga H.
Cameroon, Yaounde
Université de Yaoundé I
László, Brigitta
Hungary, Budapest
Magyar Tudomanyos Akademia
Farkas, Szilvia
Hungary, Budapest
Magyar Tudomanyos Akademia
Kisfali, Péter
Hungary, Pecs
Pécsi Tudományegyetem
Melegh, Béla I.
Hungary, Pecs
Pécsi Tudományegyetem
Esona, Mathew Dioh
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Bowen, Michael D.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Bányai, Krisztián
Hungary, Budapest
Magyar Tudomanyos Akademia
Gentsch, Jon R.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Odama, Abena M.T.
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 13
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1002/jmv.23603
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Cameroon