Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon
Human Reproduction, Volume 21, No. 7, Year 2006
Notification
URL copied to clipboard!
Description
Background: Inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8 and tumour necrosis factor-alpha (TNF-α), are important in the pathogenesis of endometriosis. We assessed the efficacy of anti-TNF monoclonal antibody (mAb, c5N), known to prevent induced endometriosis in baboons, in reducing established endometriosis in baboons. Methods: This prospective, randomized, blinded, controlled study was conducted in baboons at the Institute of Primate Research (IPR), Nairobi, Kenya. Endometriosis was induced in 18 adult female baboons (Papio anubis) with regular menstrual cycles and a normal pelvis; the extent of endometriosis was documented by videolaparoscopy 25 days later. The baboons were then randomly assigned to receive a single infusion of either placebo (n = 7, 5 ml/kg) or c5N (n = 11, 5 mg/kg). Follow-up laparoscopy was performed 25 days later to document any differences in the number, surface area and estimated volume of lesions between the two groups and between the first and the second laparoscopies in each group. Representative biopsies of at least one endometriotic lesion per baboon were obtained at the final laparoscopy. Results: Significant reductions in total surface area, estimated total volume of endometriotic lesions and both number and surface area of red lesions were observed after treatment with c5N, but not after placebo treatment, when compared to the initial laparoscopy. Conversely, a significant increase in the number of typical and red lesions was observed after placebo treatment when compared to the initial laparoscopy. Neither c5N nor placebo treatment affected the menstrual cycle. Conclusion: In baboons with induced endometriosis, anti-TNF-mAb (c5N) treatment significantly reduced the extent of endometriosis, mainly due to reducing both the number and surface area of red lesions. These findings suggest that anti-TNF-mAb therapy may have therapeutic potential for active peritoneal endometriosis. © 2006 Oxford University Press.
Authors & Co-Authors
Falconer, Henrik
Sweden, Stockholm
Karolinska Universitetssjukhuset
Mwenda, Jason Mathiu
Kenya, Nairobi
National Museums of Kenya
Chai, Daniel C.
Kenya, Nairobi
National Museums of Kenya
Wagner, C.
United States, Malvern
Centocor, Inc.
Song, Xioa yu R.
United States, Malvern
Centocor, Inc.
Mihályi, Attila M.
Belgium, Leuven
Ku Leuven
Simsa, Péter
Belgium, Leuven
Ku Leuven
Kyama, Cleophas Mutinda
Belgium, Leuven
Ku Leuven
Cornillie, Freddy J.
United States, Malvern
Centocor, Inc.
Bergqvist, Agneta
Sweden, Danderyd
Danderyds Sjukhus
Fried, Gabriel
Sweden, Stockholm
Karolinska Universitetssjukhuset
D'Hooghe, Thomas Maria
Kenya, Nairobi
National Museums of Kenya
Belgium, Leuven
Ku Leuven
Statistics
Citations: 106
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1093/humrep/del044
ISSN:
02681161
Research Areas
Cancer
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Kenya
Participants Gender
Female