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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Alcohol pretreatment alters the metabolic pattern and accelerates cocaine metabolism in pigs
Drug and Alcohol Dependence, Volume 36, No. 1, Year 1994
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Description
We investigated whether alcohol pretreatment would affect the disposition and metabolic pattern of intravenously (i.v.) administered cocaine in pigs. Six pigs (Group A) received alcohol (1 g/kg/day) and six pigs (control; Group D) received an equal volume of isocaloric dextrose 44% in water for 10 days via an intragastric tube. On day 11, arterial samples were taken for five hours following an intravenous administration of cocaine hydrochloride (4 mg/kg). Plasma concentrations of cocaine and its major metabolites were analyzed by HPLC method. Significant decrease in plasma half-life (10 ± 1.2 vs. 18.7 ± 1.4 min), and significant increases in apparent volume of distribution (73 ± 6 vs. 51 ± 31) and clearance (5.37 ± 0.6 vs. 1.82 ± 0.1 1/min) were seen in alcohol pretreated pigs as compared with control pigs (P < 0.05). Significant increases in plasma concentrations of benzoylecgonine (P < 0.05), and insignificant differences in ecgonine methyl ester and norcocaine levels were seen between the two groups. Neither ecgonine nor cocaethylene was detected in the blood samples. Our data show that alcohol administration for ten days accelerated the elimination of i.v. administered cocaine and altered its metabolic pattern in pigs. © 1994.
Authors & Co-Authors
Kambam, Jay Reddy
United States, Nashville
Vanderbilt University Hospital
Franks, John J.
United States, Nashville
Vanderbilt University Hospital
Janicki, Piotr Kazimierz
United States, Nashville
Vanderbilt University Hospital
South Africa, Cape Town
University of Cape Town
Mets, Berend
South Africa, Cape Town
University of Cape Town
Watt, Marylyn vd
South Africa, Cape Town
University of Cape Town
Hickman, Rosemary
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 6
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/0376-8716(94)90003-5
ISSN:
03768716
Research Areas
Environmental
Noncommunicable Diseases
Substance Abuse