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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Comparative genomic analysis of genogroup 1 (Wa-like) rotaviruses circulating in the USA, 2006-2009
Infection, Genetics and Evolution, Volume 28, Year 2014
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Description
Group A rotaviruses (RVA) are double stranded RNA viruses that are a significant cause of acute pediatric gastroenteritis. Beginning in 2006 and 2008, respectively, two vaccines, Rotarix™ and RotaTeq®, have been approved for use in the USA for prevention of RVA disease. The effects of possible vaccine pressure on currently circulating strains in the USA and their genome constellations are still under investigation. In this study we report 33 complete RVA genomes (ORF regions) collected in multiple cities across USA during 2006-2009, including 8 collected from children with verified receipt of 3 doses of rotavirus vaccine. The strains included 16 G1P[8], 10 G3P[8], and 7 G9P[8]. All 33 strains had a Wa like backbone with the consensus genotype constellation of G(1/3/9)-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. From maximum likelihood based phylogenetic analyses, we identified 3-7 allelic constellations grouped mostly by respective G types, suggesting a possible allelic segregation based on the VP7 gene of RVA, primarily for the G3 and G9 strains. The vaccine failure strains showed similar grouping for all genes in G9 strains and most genes of G3 strains suggesting that these constellations were necessary to evade vaccine-derived immune protection. Substitutions in the antigenic region of VP7 and VP4 genes were also observed for the vaccine failure strains which could possibly explain how these strains escape vaccine induced immune response. This study helps elucidate how RVA strains are currently evolving in the population post vaccine introduction and supports the need for continued RVA surveillance. © 2014.
Authors & Co-Authors
Roy, Sunando
United States, Atlanta
Centers for Disease Control and Prevention
Esona, Mathew Dioh
United States, Atlanta
Centers for Disease Control and Prevention
Kirkness, Ewen F.
United States, Rockville
J. Craig Venter Institute
Akopov, Asmik
United States, Rockville
J. Craig Venter Institute
Cortese, Margaret Mary
United States, Atlanta
Centers for Disease Control and Prevention
Payne, Daniel C.
United States, Atlanta
Centers for Disease Control and Prevention
Parashar, Umesh D.
United States, Atlanta
Centers for Disease Control and Prevention
Gentsch, Jon R.
United States, Atlanta
Centers for Disease Control and Prevention
Bowen, Michael D.
United States, Atlanta
Centers for Disease Control and Prevention
Drew, William Lawrence
United States, San Francisco
University of California, San Francisco
Szilâgyi, Peter G.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Weinberg, Geoffrey A.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Edwards, Kathryn M.
United States, Nashville
Vanderbilt University Medical Center
Chappell, James D.
United States, Nashville
Vanderbilt University Medical Center
Statistics
Citations: 10
Authors: 14
Affiliations: 13
Identifiers
Doi:
10.1016/j.meegid.2014.09.021
ISSN:
15671348
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study