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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: A case-control study in Uganda
Infectious Agents and Cancer, Volume 3, No. 1, Article 12, Year 2008
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Description
Background. We investigated the role of infection with genital and cutaneous human papillomavirus types (HPV) in the aetiology of ocular surface squamous neoplasia (which includes both conjunctival intraepithelial neoplasia (CIN) and carcinoma) using data and biological material collected as part of a case-control study in Uganda. Results. Among 81 cases, the prevalence of genital and cutaneous HPV types in tumour tissue did not differ significantly by histological grade of the lesion. The prevalence of genital HPV types did not differ significantly between cases and controls (both 38%; Odds ratio [OR] 1.0, 95% confidence interval [CI] 0.4-2.7, p = 1.0). The prevalence of cutaneous HPV types was 22% (18/81) among cases and 3% (1/29) among controls (OR 8.0, 95% CI 1.0-169, p = 0.04). Conclusion. We find no evidence of an association between genital HPV types and ocular surface squamous neoplasia. The prevalence of cutaneous HPV was significantly higher among cases as compared to controls. Although consistent with results from two other case-control studies, the relatively low prevalence of cutaneous HPV types among cases (which does not differ by histological grade of tumour) indicates that there remains considerable uncertainty about a role for cutaneous HPV in the aetiology of this tumour. © 2008 de Koning et al; licensee BioMed Central Ltd.
Authors & Co-Authors
De Koning, Maurits
Netherlands, Voorburg
Ddl Diagnostic Laboratory
Waddell, Keith M.
Unknown Affiliation
Magyezi, Joseph
Unknown Affiliation
Purdie, Karin
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Proby, Charlotte
United Kingdom, Dundee
University of Dundee
Harwood, Catherine Anne
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Lucas, Sebastian B.
United Kingdom, London
St Thomas' Hospital
Downing, Robert G.
Uganda, Entebbe
Uganda Virus Research Institute
Quint, Wim G.V.
Netherlands, Voorburg
Ddl Diagnostic Laboratory
Newton, Robert A.
United Kingdom, York
University of York
Statistics
Citations: 63
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1186/1750-9378-3-12
e-ISSN:
17509378
Research Areas
Cancer
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Uganda