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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Chitosan-EDTA new combination is a promising candidate for treatment of bacterial and fungal infections
Current Microbiology, Volume 62, No. 3, Year 2011
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Description
Chitosan is an attractive preparation widely used as a pharmaceutical excipient. This study aimed to evaluate the antimicrobial activities of chitosan derivatives, EDTA, and the newly developed chitosan-EDTA combination against Gram-negative and Gram-positive bacteria as well as Candida albicans. Antimicrobial activity was studied. Both minimal Inhibitory Concentrations (MIC) and minimal biocidal concentrations (MBC) were determined. Chitosan acetic acid recorded lower MIC values against Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans than those exhibited by EDTA. EDTA failed to have inhibitory activity against Enterococcus faecalis as well as MBC against any of the studied microorganisms. Chitosan acetic acid's MBC were recorded to all examined species. Checkerboard assay results indicated a synergistic antimicrobial activity of the new combination against Staphylococcus aureus and an additive effect against other microorganisms. Moreover, a short microbial exposure to chitosan-EDTA (20-30 min) caused complete eradication. Due to the continuous emergence of resistant strains, there is an urgent need to discover new antimicrobial agents. Our findings suggest the use of chitosan as an enhancing agent with antibacterial and antifungal properties in combination with EDTA in pharmaceutical preparations. © 2010 Springer Science+Business Media, LLC.
Authors & Co-Authors
El-Sharif, Amany
Egypt, Cairo
Faculty of Pharmacy
Hussain, Mohamed H.M.
Egypt, Cairo
Egyptian Petroleum Research Institute
Statistics
Citations: 55
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1007/s00284-010-9777-0
ISSN:
03438651
e-ISSN:
14320991