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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Circulating levels of the interleukin (IL)-4 receptor and of IL-18 in patients with Plasmodium falciparum malaria
Cytokine, Volume 29, No. 4, Year 2005
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Description
Circulating levels of sIL-4R, IL-18 and IFN-γ were studied by ELISA in 36 Gabonese patients with Plasmodium falciparum malaria (29 children, 7 adults). Drug induced clearance of parasitemia, studied in 22 patients with mild disease, was accompanied by a rapid decrease of sIL-4R and IFN-γ to normal values and an increase of circulating IL-18, suggesting the downregulation of a type 2 biased immune response and a dissociated type 1 responsiveness while resolving parasitemia. Comparing subgroups with hyperparasitemia/severe anemia and mild malaria, children with severe malaria had significant higher levels of sIL-4R and IFN-γ, whereas IL-18 levels were not statistically different. Furthermore, among those children, higher levels of circulating IL-18 correlated with a lower degree of parasitemia. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Perkmann, Thomas
Austria, Vienna
Medizinische Universität Wien
Winkler, Heide Maria
Austria, Vienna
Medizinische Universität Wien
Graninger, Wolfgang
Austria, Vienna
Medizinische Universität Wien
Kremsner, Peter G.
Gabon
Res. U. Albert Schweitzer Hosp.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Winkler, Stefan
Austria, Vienna
Medizinische Universität Wien
Gabon
Res. U. Albert Schweitzer Hosp.
Statistics
Citations: 20
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.cyto.2004.10.008
ISSN:
10434666
Research Areas
Infectious Diseases
Maternal And Child Health