Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Neuroprotection after a first episode of mania: A randomized controlled maintenance trial comparing the effects of lithium and quetiapine on grey and white matter volume
Translational Psychiatry, Volume 7, No. 1, Article 1011, Year 2017
Notification
URL copied to clipboard!
Description
Lithium and quetiapine are effective treatments for bipolar disorder, but their potential neuroprotective effects in humans remain unclear. A single blinded equivalence randomized controlled maintenance trial was conducted in a prospective cohort of firstepisode mania (FEM) patients (n = 26) to longitudinally compare the putative protective effects of lithium and quetapine on grey and white matter volume. A healthy control sample was also collected (n = 20). Using structural MRI scans, voxel-wise grey and white matter volumes at baseline and changes over time in response to treatment were investigated. Patients were assessed at three time points (baseline, 3 and 12-month follow-up), whereas healthy controls were assessed at two time points (baseline and 12-month follow-up). Patients were randomized to lithium (serum level 0.6 mmol l -1, n = 20) or quetiapine (flexibly dosed up to 800 mg per day, n = 19) monotherapy. At baseline, compared with healthy control subjects, patients with FEM showed reduced grey matter in the orbitofrontal cortex, anterior cingulate, inferior frontal gyrus and cerebellum. In addition, patients had reduced internal capsule white matter volume bilaterally (t1,66<3.20, P>0.01). Longitudinally, there was a significant treatment × time effect only in the white matter of the left internal capsule (F2,112 = 8.54, P>0.01). Post hoc testing showed that, compared with baseline, lithium was more effective than quetiapine in slowing the progression of white matter volume reduction after 12 months (t1,24 = 3.76, P>0.01). Our data support the role of lithium but not quetiapine therapy in limiting white matter reduction early in the illness course after FEM. © The Author(s) 2017.
Authors & Co-Authors
Berk, Michael
Australia, Geelong
Deakin University
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Australia, Geelong
Barwon Health
Australia, Melbourne
The Florey
Dandash, Orwa
Australia, Clayton
Monash University
Australia, Melbourne
Melbourne Health
Cotton, Sue M.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Fornito, Alex
Australia, Clayton
Monash University
Klauser, Paul
Australia, Clayton
Monash University
Australia, Melbourne
Melbourne Health
Liberg, Benny
Australia, Melbourne
Melbourne Health
McGorry, Patrick D.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Pantelis, Christos S.
Australia, Melbourne
The Florey
Australia, Melbourne
Melbourne Health
Statistics
Citations: 60
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1038/tp.2016.281
ISSN:
21583188
Research Areas
Mental Health
Study Design
Cohort Study