Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Relationship between plasma concentrations of valproic acid and hepatotoxicity in patients receiving high doses
Revue Neurologique, Volume 167, No. 8-9, Year 2011
Notification
URL copied to clipboard!
Description
Introduction: Valproic acid (VPA) is an anticonvulsivant drug widely prescribed in the treatment of many forms of generalized epilepsy. In literature, the incidence of liver damage induced by AVP is 0.01%. It is potentialized by the combination therapy (phenobarbital, carbamazepine). Severe hepatotoxicity is rare and appears to be independent of dose and to cause a high mortality. Methods: The aim of our study was to evaluate the relationship between plasma concentrations of AVP and the occurrence of side effects especially hepatotoxicity in patients receiving high doses of AVP. Results: In this period, 425 plasmatic AVP monitoring were carried out in our laboratory. From 128 patients treated by high doses of AVP, only 73 were included in this study. Our work showed that adverse effects in epileptics under high doses of AVP was related to the association of the AVP with other antiepileptic in particular carbamazépine, phenobarbital and benzodiazepines rather than supra-therapeutic plasmatic concentrations of AVP. The association of AVP to major antiepileptics (carbamazépine and or phenobarbital) does not seem to generate an increase in the plasmatic concentration of AVP, which was not associated with a greater risque of adverse effects. Conclusion: Consequently, clinical signs of liver toxicity may be present in AVP concentrations generally considered in the therapeutic range especially when used in high doses and or combined with antiepileptic drugs like phenobarbital or carbamazepine. © 2011 Elsevier Masson SAS. Tous droits réservés.
Authors & Co-Authors
Ghozzi, Hanène
Tunisia, Sfax
Faculty of Medicine of Sfax
Hakim, Ahmed
Tunisia, Sfax
Faculty of Medicine of Sfax
Sahnoun, Zouheir
Tunisia, Sfax
Faculty of Medicine of Sfax
Mahmoud, Lobna Ben
Tunisia, Sfax
Faculty of Medicine of Sfax
Atheymen, Rim
Tunisia, Sfax
Faculty of Medicine of Sfax
Hammami, Serria Turky
Tunisia, Sfax
Faculty of Medicine of Sfax
Zeghal, Khaled Mounir
Tunisia, Sfax
Faculty of Medicine of Sfax
Statistics
Citations: 20
Authors: 7
Affiliations: 1
Identifiers
Doi:
10.1016/j.neurol.2011.02.035
ISSN:
00353787
Study Design
Cohort Study