Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity
Clinical Microbiology and Infection, Volume 20, No. 4, Year 2014
Notification
URL copied to clipboard!
Description
New diagnostics and vaccines for tuberculosis (TB) are urgently needed, but require an understanding of the requirements for protection from/susceptibility to TB. Previous studies have used unbiased approaches to determine gene signatures in single-site populations. The present study utilized a targeted approach, reverse transcriptase multiplex ligation-dependent probe amplification (RT-MLPA), to validate these genes in a multisite study. We analysed ex vivo whole blood RNA from a total of 523 participants across four sub-Saharan countries (Ethiopia, Malawi, South Africa, and The Gambia) with differences in TB and human immunodeficiency virus (HIV) status. We found a number of genes that were expressed at significantly lower levels in participants with active disease than in those with latent TB infection (LTBI), with restoration following successful TB treatment. The most consistent classifier of active disease was FCGR1A (high-affinity IgG Fc receptor 1 (CD64)), which was the only marker expressed at significantly higher levels in participants with active TB than in those with LTBI before treatment regardless of HIV status or genetic background. This is the first study to identify a biomarker for TB that is not affected by HIV status or geo-genetic differences. These data provide valuable clues for understanding TB pathogenesis, and also provide a proof-of-concept for the use of RT-MLPA in rapid and inexpensive validation of unbiased gene expression findings. © 2013 European Society of Clinical Microbiology and Infectious Diseases.
Authors & Co-Authors
Sutherland, J. S.
Gambia, Fajara
Medical Research Council Unit
Loxton, A. G.
South Africa, Stellenbosch
Stellenbosch University
Haks, M. C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Kassa, Desta
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Ambrose, Lyn R.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Lee, Jisook
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ran, L.
Netherlands, Utrecht
University Medical Center Utrecht
van Baarle, Debbie
Netherlands, Utrecht
University Medical Center Utrecht
Maertzdorf, Jeroen
Germany, Berlin
Max Planck Institute for Infection Biology
Howe, R.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Mayanja-Kizza, Harriet
Uganda, Kampala
Makerere University
Boom, W. Henry
United States, Cleveland
Case Western Reserve University
Thiel, Bonnie A.
United States, Cleveland
Case Western Reserve University
Crampin, Amelia Catharine
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Hanekom, Willem Albert
South Africa, Cape Town
University of Cape Town
Ota, Martin O.C.
Gambia, Fajara
Medical Research Council Unit
Dockrell, Hazel M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Walzl, Gerhard
South Africa, Stellenbosch
Stellenbosch University
Kaufmann, Stefan H.E.
Germany, Berlin
Max Planck Institute for Infection Biology
Ottenhoff, Tom H.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Beyers, Nulda
South Africa, Stellenbosch
Stellenbosch University
Van Helden, Paul D.
South Africa, Stellenbosch
Stellenbosch University
Thompson, B.
South Africa, Stellenbosch
Stellenbosch University
Loxton, A.
South Africa, Stellenbosch
Stellenbosch University
Chegou, Novel N.
South Africa, Stellenbosch
Stellenbosch University
Black, Gillian Frances
South Africa, Stellenbosch
Stellenbosch University
Kriel, D.
South Africa, Stellenbosch
Stellenbosch University
Stanley, Kim
South Africa, Stellenbosch
Stellenbosch University
Golakai, Hawa Jande
South Africa, Stellenbosch
Stellenbosch University
Du Plessis, Nelita M.
South Africa, Stellenbosch
Stellenbosch University
Van Der Spuy, Gian D.
South Africa, Stellenbosch
Stellenbosch University
Ota, Martin Okechukwu C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sutherland, Jayne
Gambia, Banjul
Medical Research Council Laboratories Gambia
Adetifa, Ifedayo
Gambia, Banjul
Medical Research Council Laboratories Gambia
Togun, Toyin Omotayo
Gambia, Banjul
Medical Research Council Laboratories Gambia
Donkor, Simon A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Antonio, Martin
Gambia, Banjul
Medical Research Council Laboratories Gambia
Hill, Philip C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Henry Boom, W.
United States, Cleveland
Case Western Reserve University
Chervenak, Keith A.
United States, Cleveland
Case Western Reserve University
Thiel, Bonnie A.
United States, Cleveland
Case Western Reserve University
Heaphy, Emily G.
United States, Cleveland
Case Western Reserve University
Joloba, Moses Lutaakome
Uganda, Kampala
Makerere University
Zalwango, Sarah K.
Uganda, Kampala
Makerere University
Nsereko, Mary
Uganda, Kampala
Makerere University
Okwera Hussein Kisingo, B.
Uganda, Kampala
Makerere University
Baseke, Joy
Uganda, Kampala
Makerere University
Buteme, Helen Koyokoyo
Uganda, Kampala
Makerere University
Nalukwango, S.
Uganda, Kampala
Makerere University
Crampin, Mia
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
French, N.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Ngwira, Bagrey M.M.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Ben-Smith, Anne W.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Watkins, Kate
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Simukonda, Felanji D.
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Mvula, Hazzie
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Chilongo, Femia
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Saul, Jacky
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Branson, Keith
Malawi, Chilumba
Malawi Epidemiology and Intervention Research Unit
Lalor, Maeve K.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Smith, Steven G.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gorak-Stolinska, Patricia M.A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hur, Yun-gyoung
United Kingdom, London
London School of Hygiene & Tropical Medicine
Blitz, Rose
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ottenhoff, Tom Henricus Maria
Netherlands, Leiden
Leids Universitair Medisch Centrum
Haks, Mariëlle C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Franken, Kees L.M.C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Joosten, Simone A.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Friggen, Annemieke H.
Netherlands, Leiden
Leids Universitair Medisch Centrum
van Meijgaarden, Krista E.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Geluk, Annemieke
Netherlands, Leiden
Leids Universitair Medisch Centrum
Klein, Michèl R.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Howe, Rawleigh Craig
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Yamuah, Lawrence K.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Mihret, Adane
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Asseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Aytenew, Milikit
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Assefa, Yilikal
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Girma, Selfu
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Iwnetu, Rachel
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Tafesse, Mesfin
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Miedema, Frank F.
Netherlands, Utrecht
University Medical Center Utrecht
Ran, Leonie J.
Netherlands, Utrecht
University Medical Center Utrecht
Jacobi, Ronald H.J.
Netherlands, Utrecht
University Medical Center Utrecht
Abebe, Almaz
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Gebremicael, Gebremedhin
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Mesele, Tsehayenesh
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Tegbaru, Belete
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Alemayehu, Yodit
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Andersen, Peter Lawætz
Denmark, Copenhagen
Statens Serum Institut
Doherty, Timothy Mark
Denmark, Copenhagen
Statens Serum Institut
Rosenkrands, Ida
Denmark, Copenhagen
Statens Serum Institut
Weldingh, Karin N.
Denmark, Copenhagen
Statens Serum Institut
Hanekom, Willem A.
South Africa, Cape Town
University of Cape Town
Scriba, Thomas Jens
South Africa, Cape Town
University of Cape Town
Hughes, Jane E.
South Africa, Cape Town
University of Cape Town
Mohamed, Hassan
South Africa, Cape Town
University of Cape Town
Abel, Brian
South Africa, Cape Town
University of Cape Town
Bowmaker, Mark
South Africa, Cape Town
University of Cape Town
M Kagina, Benjamin Mugo N.
South Africa, Cape Town
University of Cape Town
Kwong Chung, William
South Africa, Cape Town
University of Cape Town
Mulenga, Humphrey
South Africa, Cape Town
University of Cape Town
Keyser, Alana T.
South Africa, Cape Town
University of Cape Town
Erasmus, Mzwandile
South Africa, Cape Town
University of Cape Town
Hussey, Gregory D.
South Africa, Cape Town
University of Cape Town
Sadoff, Jerald C.
Unknown Affiliation
Sizemore, Donata R.
Unknown Affiliation
Barker, Lew F.
Unknown Affiliation
Brennan, Michael James
Unknown Affiliation
Weichold, Frank F.
Unknown Affiliation
Malone, Angela
Unknown Affiliation
Mueller, Stefanie
Unknown Affiliation
Geiter, Lawrence J.
Unknown Affiliation
Schoolnik, Gary K.
United States, Palo Alto
Stanford University
Dolganov, Gregory M.
United States, Palo Alto
Stanford University
Van, Tran T.
United States, Palo Alto
Stanford University
Kaufmann, Stefan H.E.
Germany, Berlin
Max Planck Institute for Infection Biology
Golinski, Robert
Germany, Berlin
Max Planck Institute for Infection Biology
Parida, Shreemanta K.
Germany, Berlin
Max Planck Institute for Infection Biology
Jacobsen, Marc
Germany, Berlin
Max Planck Institute for Infection Biology
Weiner, January Mikolaj
Germany, Berlin
Max Planck Institute for Infection Biology
Statistics
Citations: 59
Authors: 122
Affiliations: 15
Identifiers
Doi:
10.1111/1469-0691.12383
ISSN:
1198743X
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Ethiopia
Gambia
Malawi
South Africa