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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Trypanosoma cruzi infection in diabetic mice
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 82, No. 1, Year 1988
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Description
The course of infection due to Trypanosoma cruzi (Brazil strain) was examined in mutant and streptozotocin (STZ)-induced diabetic mice. Mutant diabetic mice ( +db +db) are obese, have elevated blood glucose levels, normal insulin levels and impaired cell mediated immunity (CMI). Their littermates ( m+ m+, m+ +db) are of normal weight, normoglycaemic and immunocompetent. Infected +db +db mice died within 20-25 d after infection (AI) with a mean peak parasitaemia of 6 × 106 trypomastigotes/ml accompanied by heavy tissue parasitism. The nondiabetic littermates had low, transient, parasitaemia, no tissue parasitism, and 100% survival. Immune mouse serum (IMS) was given to infected +db +db mice thrice weekly beginning on day l AI. During IMS treatment, parasitaemia remained significantly lower than in untreated mice. However, when IMS treatment was discontinued parasitaemia rose and mortality ensued. To examine the effects of hyperglycaemia in the absence of other variables such as genetics or CMI, T. cruzi infection was studied in STZ-induced diabetic mice. Normal C57BL/6 mice, resistant to infection with the Brazil strain, exhibited low transient parasitaemia and no mortality. In contrast, STZ-induced hyperglycaemic C57BL/6 mice developed high parasitaemia and 100% mortality by day 40 AI. When these hyperglycaemic mice were treated with insulin continuously by pump, their blood glucose levels returned to normal but parasitaemia and mortality were unchanged. These data indicate that hyperglycaemia significantly increases parasitaemia and mortality in mice infected with T. cruzi. © 1988.
Authors & Co-Authors
Tanowitz, Herbert Bernard
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Amole, B. O.
Nigeria, Ife
Obafemi Awolowo University
Hewlett, Dial
United States, New York
Our Lady of Mercy Medical Center
Wittner, M.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Statistics
Citations: 57
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/0035-9203(88)90271-4
ISSN:
00359203
Research Areas
Genetics And Genomics