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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Natural recombination event within the capsid genomic region leading to a chimeric strain of human enterovirus B
Journal of Virology, Volume 81, No. 17, Year 2007
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Description
Recombination between two strains is a known phenomenon for enteroviruses replicating within a single cell. We describe a recombinant strain recovered from human stools, typed as coxsackievirus B4 (CV-B4) and CV-B3 after partial sequencing of the VP1 and VP2 coding regions, respectively. The strain was neutralized by a polyclonal CV-B3-specific antiserum but not by a CV-B4-specific antiserum. The nucleotide sequence analysis of the whole structural genomic region showed the occurrence of a recombination event at position 1950 within the VP3 capsid gene, in a region coding for the 2b antigenic site previously described for CV-B3. This observation evidences for the first time the occurrence of an interserotypic recombination within the VP2-VP3-VP1 capsid region between two nonpoliovirus enterovirus strains. The neutralization pattern suggests that the major antigenic site is located within the VP2 protein. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Bouslama, Lamjed
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Nasri, Dorsaf
Tunisia, Monastir
Faculté de Pharmacie de Monastir
France, Saint-priest-en-jarez
Groupe Sur L'immunité Des Muqueuses et Des Agents Pathogènes
Chollet, Lionel
France, La Seyne-sur-mer
Hospital of Toulon-la Seyne Sur Mer
Belguith, Khaoula
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Bourlet, Thomas
France, Saint-priest-en-jarez
Groupe Sur L'immunité Des Muqueuses et Des Agents Pathogènes
Aouni, Mahjoub
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Pozzetto, Bruno
France, Saint-priest-en-jarez
Groupe Sur L'immunité Des Muqueuses et Des Agents Pathogènes
Pillet, Sylvie
France, Saint-priest-en-jarez
Groupe Sur L'immunité Des Muqueuses et Des Agents Pathogènes
Statistics
Citations: 46
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1128/JVI.00180-07
ISSN:
0022538X
Research Areas
Genetics And Genomics