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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Diversity of rotavirus strains circulating in Haiti before and after introduction of monovalent vaccine
IJID Regions, Volume 4, Year 2022
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Description
Background: Haiti introduced a monovalent human group A rotavirus (RVA) vaccine (Rotarix) into its routine infant immunization program in April 2014. The goal of the surveillance program was to characterize RVA strains circulating in Haiti before and after RVA vaccine introduction. Methods: Stool samples were collected from children <5 years old presenting with acute gastroenteritis at 16 hospitals in Haiti. RVA antigen enzyme immunoassay (EIA) testing was performed, and G and P genotypes were determined for positive specimens. In this study, genotype data for samples collected from May 2012 through April 2014 (the pre-vaccine introduction era) and May 2014 through July 2019 (post-vaccine introduction era) were analyzed. Results: A total of 809 specimens were tested by the Centers for Disease Control and Prevention. During the pre-vaccine introduction era (May 2012 through April 2014), G12P[8] was the predominant genotype, detected in 88–94% of specimens. There was a high prevalence of the equine-like G3P[8] genotype among Haitian children with RVA after vaccine introduction. Conclusions: The predominance of equine-like G3P[8] in three of five RVA seasons post-vaccine introduction suggests possible vaccine-specific selection pressure in Haiti. These temporal variations in RVA genotype predominance will require continued monitoring in Haiti as the vaccination program continues. © 2022
Authors & Co-Authors
Esona, Mathew Dioh
United States, Atlanta
Centers for Disease Control and Prevention
Leshem, Eyal
United States, Atlanta
Centers for Disease Control and Prevention
Aliabadi, Negar
United States, Atlanta
Centers for Disease Control and Prevention
Désormeaux, Anne Marie
Haiti, Port-au-prince
Cdc Country Office
Fitter, David L.
Haiti, Port-au-prince
Cdc Country Office
Grant-Greene, Yoran
Haiti, Port-au-prince
Cdc Country Office
Tate, Jacqueline E.
United States, Atlanta
Centers for Disease Control and Prevention
Boncy, Jacques
Haiti, Port-au-prince
Laboratoire National de Santé Publique
Patel, Roopal
Haiti, Port-au-prince
Cdc Country Office
Burnett, Eleanor M.
United States, Atlanta
Centers for Disease Control and Prevention
Juin, Stanley
Haiti, Port-au-prince
Cdc Country Office
Parashar, Umesh D.
United States, Atlanta
Centers for Disease Control and Prevention
Bowen, Michael D.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1016/j.ijregi.2022.07.007
ISSN:
27727076
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study