Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity
Cell Reports, Volume 13, No. 7, Year 2015
Notification
URL copied to clipboard!
Description
Trace elements are essential to all mammals, but their distribution and utilization across species and organs remains unclear. Here, we examined 18 elements in the brain, heart, kidney, and liver of 26 mammalian species and report the elemental composition of these organs, the patterns of utilization across the species, and their correlation with body mass and longevity. Across the organs, we observed distinct distribution patterns for abundant elements, transition metals, and toxic elements. Some elements showed lineage-specific patterns, including reduced selenium utilization in African mole rats, and positive correlation between the number of selenocysteine residues in selenoprotein P and the selenium levels in liver and kidney across mammals. Body mass was linked positively to zinc levels, whereas species lifespan correlated positively with cadmium and negatively with selenium. This study provides insights into the variation of mammalian ionome by organ physiology, lineage specialization, body mass, and longevity. © 2015 The Authors.
Authors & Co-Authors
Ma, Siming
United States, Boston
Harvard Medical School
Lee, Sang Goo
United States, Boston
Harvard Medical School
South Korea, Seoul
Ewha Womans University
Kim, Eun-bae
South Korea, Seoul
Ewha Womans University
South Korea, Chuncheon
Kangwon National University
Park, Thomas J.
United States, Chicago
University of Illinois at Chicago
Seluanov, Andrei
United States, Rochester
University of Rochester
Gorbunova, Vera A.
United States, Rochester
University of Rochester
Buffenstein, Rochelle B.
United States, San Antonio
University of Texas Health Science Center at San Antonio
United States, San Francisco
Calico Llc
Gladyshev, Vadim N.
United States, Boston
Harvard Medical School
Statistics
Citations: 48
Authors: 8
Affiliations: 8
Identifiers
Doi:
10.1016/j.celrep.2015.10.014
ISSN:
22111247
Research Areas
Environmental