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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of combined maternal and infant vitamin D supplementation on vitamin D status of exclusively breastfed infants
Maternal and Child Nutrition, Volume 5, No. 1, Year 2009
Notification
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Description
Severe vitamin D deficiency in mothers and their breastfed infants is a significant health problem in the Middle East. Supplementation of the breastfed infant alone with the recommended dose of vitamin D may be insufficient in high-risk population. We investigated the effect of combined maternal and infant vitamin D supplementation on vitamin D status of the breastfed infant. We examined also the effect of supplementation on vitamin D antirachitic activity of breast milk in a subset of mothers. Healthy breastfeeding mothers (n = 90) were randomly assigned to 2000IU daily (group 1) or 60000 IU monthly (group 2) of vitamin D2, and all their infants (n = 92) received 400 IU daily of vitamin D2 for 3 months. Most infants had vitamin D deficiency - 25-hydroxyvitamin D [25(OH)D] ≤37.5 nmol L-1 - at study entry. Serum 25(OH)D concentrations at 3 months increased significantly from baseline in infants of mothers in group 1 (13.9 ± 8.6 vs. 49.6 ± 18.5 nmol L-1, P < 0.0001) and group 2 (13.7 ± 12.1 vs. 44.6 ± 15.0 nmol L-1, P < 0.0001). Maternal and infant serum 25(OH)D concentrations correlated positively at baseline (r = 0.36, P = 0.01) and 3 months (r = 0.46, P = 0.002). Milk antirachitic activity increased from undetectable (<20 IU L-1) to a median of 50.9 IU L-1. In conclusion, combined maternal and infant vitamin D supplementation was associated with a threefold increase in infants' serum 25(OH)D concentrations and a 64% reduction in the prevalence of vitamin D deficiency without causing hypervitaminosis D. © 2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Saadi, Hussein F.
United Arab Emirates, Al Ain
United Arab Emirates University
Dawodu, Adekunle H.
United Arab Emirates, Al Ain
United Arab Emirates University
Afandi, Bachar O.
United Arab Emirates, Al Ain
Tawam Hospital
Zayed, R.
United Arab Emirates, Al Ain
General Authority for Health Services for the Emirate of Abu Dhabi
Benedict, Sheela
United Arab Emirates, Al Ain
United Arab Emirates University
Nagelkerke, Nico J.D.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Hollis, Bruce W.
United States, Charleston
Medical University of South Carolina
Statistics
Citations: 66
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1111/j.1740-8709.2008.00145.x
ISSN:
17408695
e-ISSN:
17408709
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study