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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue
BMC Genomics, Volume 15, No. 1, Article 128, Year 2014
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Description
Background: Cathelicidins comprise a major group of host-defence peptides. Conserved across a wide range of species, they have several functions related to host defence. Only one cathelicidin has been found in humans but several cathelicidin genes occur in the bovine genome. We propose that these molecules may have a protective role against mastitis. The aim of this study was to characterise the cathelicidin gene-cluster in the bovine genome and to identify sites of expression in the bovine mammary gland.Results: Bioinformatic analysis of the bovine genome (BosTau7) revealed seven protein-coding cathelicidin genes, CATHL1-7, including two identical copies of CATHL4, as well as three additional putative cathelicidin genes, all clustered on the long arm of chromosome 22. Six of the seven protein-coding genes were expressed in leukocytes extracted from milk of high somatic cell count (SCC) cows. CATHL5 was expressed across several sites in the mammary gland, but did not increase in response to Staphylococcus aureus infection.Conclusions: Here, we characterise the bovine cathelicidin gene cluster and reconcile inconsistencies in the datasets of previous studies. Constitutive cathelicidin expression in the mammary gland suggests a possible role for these host defence peptides its protection. © 2014 Whelehan et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3932039/bin/1471-2164-15-128-S1.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3932039/bin/1471-2164-15-128-S2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3932039/bin/1471-2164-15-128-S3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3932039/bin/1471-2164-15-128-S4.pdf
Authors & Co-Authors
Whelehan, Cormac J.
Ireland, Dublin
Trinity College Dublin
Barry-Reidy, Anne
Ireland, Dublin
Trinity College Dublin
Meade, Kieran G.
Ireland, Dunsany
Grange Research Centre
Eckersall, Peter David
United Kingdom, Glasgow
University of Glasgow
Chapwanya, Aspinas
South Africa, Pretoria
University of Pretoria
Narciandi, Fernando
Ireland, Dublin
Trinity College Dublin
Lloyd, Andrew
Ireland, Waterford
South East Technological University
O'Farrelly, Cliona
Ireland, Dublin
Trinity College Dublin
Statistics
Citations: 8
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2164-15-128
e-ISSN:
14712164
Research Areas
Genetics And Genomics