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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Infections in infants during the first 12 months of life: Role of placental malaria and environmental factors
PLoS ONE, Volume 6, No. 11, Article e27516, Year 2011
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Description
Background: The association between placental malaria (PM) and first peripheral parasitaemias in early infancy was assessed in Tori Bossito, a rural area of Benin with a careful attention on transmission factors at an individual level. Methodology: Statistical analysis was performed on 550 infants followed weekly from birth to 12 months. Malaria transmission was assessed by anopheles human landing catches every 6 weeks in 36 sampling houses and season defined by rainfall. Each child was located by GPS and assigned to the closest anopheles sampling house. Data were analysed by survival Cox models, stratified on the possession of insecticide-treated mosquito nets (ITNs) at enrolment. Principal Findings: Among infants sleeping in a house with an ITN, PM was found to be highly associated to first malaria infections, after adjusting on season, number of anopheles, antenatal care (ANC) visits and maternal severe anaemia. Infants born from a malaria infected placenta had a 2.13 fold increased risk to present a first malaria infection than those born from a non infected placenta ([1.24-3.67], p<0.01) when sleeping in a house with an ITN. The risk to present a first malaria infection was increased by 3.2 to 6.5, according to the level of anopheles exposure (moderate or high levels, compared to the absence of anopheles). Conclusions: First malaria infections in early childhood can be attributed simultaneously to both PM and high levels of exposure to infected anopheles. Protective measures as Intermittent Preventive Treatment during pregnancy (IPTp) and ITNs, targeted on both mothers and infants should be reinforced, as well as the research on new drugs and insecticides. In parallel, investigations on placental malaria have to be strengthened to better understand the mechanisms involved, and thus to protect adequately the infants high risk group. © 2011 Le Port et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3214070/bin/pone.0027516.s001.docx
Authors & Co-Authors
Le Port, Agnes
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Watier, Laurence
France, Paris
Inserm
France, Paris
Pharmacoépidémiologie et Maladies Infectieuses
France, Paris
Institut Pasteur, Paris
Cottrell, Gilles
France, Paris
Université Paris Cité
Benin
Institut de Recherche Pour le Développement Ird
Ouedraogo, Smaïla M.
France, Paris
Université Paris Cité
Benin
Institut de Recherche Pour le Développement Ird
Dechavanne, Célia
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Pierrat, Charlotte
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Rachas, Antoine
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Bouscaillou, Julie
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Bouraïma, Aziz
Benin, Cotonou
Institut Des Sciences Biomédicales Appliquées Isba
Massougbodji, Achille
Benin
Faculté Des Sciences de la Santé Fss
Fayomi, Benjamin Eboum
Benin, Cotonou
Institut Des Sciences Biomédicales Appliquées Isba
Thiébaut, Anne C.M.
France, Paris
Inserm
France, Paris
Pharmacoépidémiologie et Maladies Infectieuses
France, Paris
Institut Pasteur, Paris
Chandre, Fabrice
France, Montpellier
Ird Centre de Montpellier
Migot-Nabias, Florence
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Martin-Prevel, Y.
France, Montpellier
Nutrition et Alimentation Des Populations Aux Suds
Garcia, André
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Cot, Michel
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Statistics
Citations: 77
Authors: 17
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pone.0027516
e-ISSN:
19326203
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Approach
Quantitative
Study Locations
Benin