Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide meta-analysis identifies new susceptibility loci for migraine
Nature Genetics, Volume 45, No. 8, Year 2013
Notification
URL copied to clipboard!
Description
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10-8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B. © 2013 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Anttila, Verneri
United Kingdom, Hinxton
Wellcome Sanger Institute
Finland, Helsinki
Helsingin Yliopisto
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Winsvold, Bendik S.
United Kingdom, Hinxton
Wellcome Sanger Institute
Norway, Oslo
Oslo Universitetssykehus
Gormley, Padhraig
United Kingdom, Hinxton
Wellcome Sanger Institute
Kurth, Tobias
France, Paris
Inserm
France, Bordeaux
Université de Bordeaux
United States, Boston
Brigham and Women's Hospital
Bettella, Francesco
Iceland, Reykjavik
Decode Genetics
McMahon, George
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Kallela, Mikko
Finland, Helsinki
Helsinki University Hospital
Malik, Rainer
Germany, Munich
Klinikum Der Universität München
De Vries, Boukje
Netherlands, Leiden
Leids Universitair Medisch Centrum
Terwindt, Gisela
Netherlands, Leiden
Leids Universitair Medisch Centrum
Medland, Sarah E.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Todt, Unda
Germany, Ulm
Universität Ulm
McArdle, Wendy L.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Quaye, Lydia
United Kingdom, London
King's College London
Koiranen, Markku J.
Finland, Oulu
Oulun Yliopisto
Finland, Oulu
Oulu University Hospital
Ikram, Mohammad Kamran
Netherlands, Rotterdam
Erasmus Mc
Lehtimäki, Terho J.
Finland, Tampere
Tampere University
Stam, Anine H.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Ligthart, Lannie
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Wedenoja, Juho
Finland, Helsinki
Helsingin Yliopisto
Dunham, Ian
United Kingdom, London
Wellcome Trust
Neale, Benjamin M.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Palta, Priit
United Kingdom, Hinxton
Wellcome Sanger Institute
Finland, Helsinki
Helsingin Yliopisto
Hämäläinen, Eija I.
United Kingdom, Hinxton
Wellcome Sanger Institute
Finland, Helsinki
Helsingin Yliopisto
Schürks, Markus
Germany, Essen
Universitätsklinikum Essen
Rose, Lynda M.
United States, Boston
Brigham and Women's Hospital
Buring, Julie E.
United States, Boston
Brigham and Women's Hospital
Ridker, Paul M.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Steinberg, Stacy
Iceland, Reykjavik
Decode Genetics
Stefánsson, Hreinn
Iceland, Reykjavik
Decode Genetics
Jakobsson, Finnbogi
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Lawlor, Debbie A.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Evans, David M.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Ring, Susan M.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Färkkilä, Martti A.
Finland, Helsinki
Helsinki University Hospital
Artto, Ville
Finland, Helsinki
Helsinki University Hospital
Kaunisto, Mari Anneli
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Folkhälsan
Freilinger, Tobias
Germany, Munich
Klinikum Der Universität München
Schoenen, Jean E.
Belgium, Liege
Université de Liège
Frants, Rune R.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Pelzer, Nadine
Netherlands, Leiden
Leids Universitair Medisch Centrum
Weller, Claudia M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Zielman, Ronald
Netherlands, Leiden
Leids Universitair Medisch Centrum
Heath, Andrew Christopher
United States, St. Louis
Washington University School of Medicine in St. Louis
Madden, Pamela A.F.
United States, St. Louis
Washington University School of Medicine in St. Louis
Montgomery, Grant W.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Martin, Nicholas G.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Borck, Guntram
Germany, Ulm
Universität Ulm
Göbel, Hartmut
Germany, Kiel
Kiel Migraine and Headache Centre
Heinze, Axel
Germany, Kiel
Kiel Migraine and Headache Centre
Kuhn, Katja Heinze
Germany, Kiel
Kiel Migraine and Headache Centre
Williams, Frances M.K.
United Kingdom, London
King's College London
Hartikainen -, Anna Liisa
Finland, Oulu
Oulu University Hospital
Finland, Oulu
Oulun Yliopisto
Pouta, Anneli
Finland, Oulu
Oulun Yliopisto
Finland, Oulu
Oulu University Hospital
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Van Den Ende, Joyce
Netherlands, Rotterdam
Erasmus Mc
Uitterlinden, André G.
Netherlands, Rotterdam
Erasmus Mc
Hofman, Albert
Netherlands, Rotterdam
Erasmus Mc
Amin, Najaf A.
Netherlands, Rotterdam
Erasmus Mc
Hottenga, Jouke Jan
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Vink, Jacqueline M.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Heikkilä, Kauko V.
Finland, Helsinki
Helsingin Yliopisto
Alexander, Michael
Germany, Bonn
Universität Bonn
Myhsok, Bertram Muller
Germany, Munich
Max Planck Institute of Psychiatry
Germany, Munich
Munich Cluster for Systems Neurology Synergy
Schreiber, Stefan W.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Meitinger, Thomas A.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Klinikum Rechts Der Isar
Wichmann, Heinz-Erich Erich
Germany, Munich
Ludwig-maximilians-universität München
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Klinikum Der Universität München
Aromaa, Arpo
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Eriksson, Johan Gunnar
Finland, Helsinki
Folkhälsan
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsinki University Hospital
Finland, Vaasa
Vasa Central Sjukhus
Finland, Helsinki
Helsingin Yliopisto
Traynor, B. J.
United States, Bethesda
National Institute on Aging Nia
Trabzuni, Daniah
United Kingdom, London
Ucl Queen Square Institute of Neurology
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Rossin, Elizabeth
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Lage, Kasper
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Denmark, Lyngby
Technical University of Denmark
Denmark, Copenhagen
Københavns Universitet
Jacobs, Suzanne B.R.
United States, Cambridge
Broad Institute
Gibbs, J. Raphael
United States, Bethesda
National Institute on Aging Nia
United Kingdom, London
Ucl Queen Square Institute of Neurology
Birney, Ewan
United Kingdom, London
Wellcome Trust
Kaprio, Jaakko A.
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Penninx, Brenda W. J. H.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Boomsma, Dorret I.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
van Duijn, Cornelia M.
Netherlands, Rotterdam
Erasmus Mc
Raitakari, Olli T.
Finland, Turku
Lääketieteellinen Tiedekunta
Finland, Turku
Turun Yliopistollinen Keskussairaala
J̈arvelin, Märjo Riitta R.
Finland, Oulu
Oulun Yliopisto
Finland, Oulu
Oulu University Hospital
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
United Kingdom, London
Public Health England
Zwart, John Anker
Norway, Oslo
Oslo Universitetssykehus
Cherkas, Lynn
United Kingdom, London
King's College London
Strachan, David Peter
United Kingdom, London
St George’s, University of London
Kubisch, Christian
Germany, Ulm
Universität Ulm
Ferrari, Michel D.
Netherlands, Leiden
Leids Universitair Medisch Centrum
van den Maagdenberg, Arn Mjm
Netherlands, Leiden
Leids Universitair Medisch Centrum
Dichgans, Martin
Germany, Munich
Klinikum Der Universität München
Germany, Munich
Munich Cluster for Systems Neurology Synergy
Wessman, Maija
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Folkhälsan
Smith, George D.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Stefánsson, Kári
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Daly, Mark J.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Nyholt, Dale
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Chasman, Daniel I.
United States, Boston
Brigham and Women's Hospital
Palotie, Aarno V.
United Kingdom, Hinxton
Wellcome Sanger Institute
Finland, Helsinki
Helsingin Yliopisto
United States, Cambridge
Broad Institute
Statistics
Citations: 95
Authors: 95
Affiliations: 50
Identifiers
Doi:
10.1038/ng.2676
ISSN:
10614036
e-ISSN:
15461718
Study Design
Cross Sectional Study
Study Approach
Quantitative
Systematic review