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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Cerebellar white matter injury following systemic endotoxemia in preterm fetal sheep
Neuroscience, Volume 160, No. 3, Year 2009
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Description
Injury to the cerebellum and brainstem is becoming increasingly recognized in prematurely born infants. The role of infection/inflammation in mediating damage to those structures in the preterm brain is largely unknown. Preterm fetal sheep (70% gestation) received either saline-vehicle (control group; n=11) or Escherichia coli lipopolysaccharide (100 ng intravenous [i.v.]; lipopolysaccharide [LPS] group; n=9), and were allowed to recover for 3 days before sacrifice. A diffuse pattern of cerebellar white matter damage was observed in all animals exposed to LPS, while focal cerebellar white matter lesions were observed in three out of nine animals, and an intragyral white matter hemorrhage in one animal. Cerebellar white matter injury was associated with a statistically significant loss of oligodendrocyte transcription factor-2-positive oligodendrocytes and increased terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive cell counts. Ionized calcium binding adapter molecule 1 (Iba1)-positive cells which had the morphology of activated microglia were commonly observed in areas of injury. There was no obvious injury to the cerebellar cortex or to cerebellar Purkinje cells, and no obvious injury in any region of the brainstem. These data provide support for a role of infection/inflammation in selective white matter injury in the immature cerebellum, and demonstrate a differential vulnerability of the brainstem and cerebellar white matter to injury at this time. © 2009 IBRO.
Authors & Co-Authors
Dean, J. M.
Sweden, Gothenburg
Sahlgrenska Akademin
Farrag, D.
Sweden, Gothenburg
Sahlgrenska Akademin
Zahkouk, S. A.M.
Egypt, Cairo
Al-azhar University
El Zawahry, E. Y.I.
Egypt, Cairo
Al-azhar University
Hagberg, Henrik E.
Sweden, Gothenburg
Sahlgrenska Akademin
United Kingdom, London
Imperial College London
Kjellmer, I.
Sweden, Gothenburg
Sahlgrenska Akademin
Mallard, Carina
Sweden, Gothenburg
Sahlgrenska Akademin
Statistics
Citations: 46
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.neuroscience.2009.02.071
ISSN:
03064522
Research Areas
Violence And Injury
Study Design
Randomised Control Trial