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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association of interleukin-18 polymorphisms and plasma level with the outcome of chronic HCV infection
Journal of Medical Virology, Volume 80, No. 4, Year 2008
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Description
Hepatitis C virus (HCV) infection is the main cause of chronic liver disease throughout the world, and may progress to cirrhosis and hepatocellular carcinoma (HCC). Immunological factors, especially cytokines and some host genetic variations, rather than direct HCV action, seem to play an important role in the pathogenesis of HCV infection. Elevated levels of interleukin-18 (IL-18) were described previously for chronically (HCV)-infected patients. This study is aimed at investigating IL-18 promoter polymorphisms (-607C/A and -137G/C) in HCV-infected patients with different disease severities (chronic hepatitis C, liver cirrhosis and HCC) and establishing an association between these polymorphisms and IL-18 plasma concentration with the outcome of chronic HCV infection. The carriage of at least one C allele at position -607 (CC + CA) was associated with a higher risk of cirrhosis and HCC (P = 0.032). Compared with controls, HCV-infected patients had significantly higher levels of IL-18 (P = 0.0001) that correlate with disease severity (P = 0.01, P = 0.001, P = 0.0006, respectively). In conclusion, we supposed a possible implication of IL-18 promoter polymorphisms in the pathogenesis of chronic HCV infection. © 2008 Wiley-Liss, Inc.
Authors & Co-Authors
Bouzgarrou, Nadia
Tunisia, Monastir
Faculté de Médecine de Monastir
Hassen, Elham
Tunisia, Monastir
Faculté de Médecine de Monastir
Schvoerer, Évelyne
France, Strasbourg
Institute of Virology
Stoll-Keller, F.
France, Strasbourg
Institute of Virology
Bahri, O.
Tunisia, Tunis
Institut Pasteur de Tunis
Gabbouj, Sallouha
Tunisia, Monastir
Faculté de Médecine de Monastir
Cheikh, Imed
Tunisia, Tunis
Hôpital la Rabta
Maamouri, Nadia
Tunisia, Tunis
Hôpital la Rabta
Mammi, N.
Tunisia, Tunis
Hôpital la Rabta
Saffar, Hammouda
Tunisia, Monastir
Chu Fattouma-bourguiba
Trabelsi, Abdelhalim
Tunisia, Sousse
Chu Sahloul
Triki, Henda
Tunisia, Tunis
Institut Pasteur de Tunis
Chouchane, Lotfi
Tunisia, Monastir
Faculté de Médecine de Monastir
Statistics
Citations: 52
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1002/jmv.21079
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases