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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children
Epidemiology and Infection, Volume 111, No. 1, Year 1993
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Description
Rates of acquisition and mean duration of nasal carriage of different serotypes of Streptococcus pneumoniae have been estimated by fitting a stochastic model to longitudinal carriage data in children from Papua New Guinea. Immunogenicity and two indices of relative invasiveness were determined for each serotype. Immunogenic serotypes were less frequently acquired and were carried for shorter periods, but no relationship between immunogenicity and invasiveness was apparent using either index of invasiveness. Frequent invasion was associated with a high acquisition rate and high frequency and prolonged duration of carriage. Carriage studies can provide a broad indication of which serotypes cause invasive disease but not the proportion of disease due to individual serotypes; some serotypes which cause invasive disease (e.g. serotype 46) are not found even in extensive carriage studies. The antibiotic resistance of carriage organisms, however, does approximate the resistance patterns of invasive organisms and thus may be used to monitor changing patterns of antimicrobial susceptibility in the community. © 1993, Cambridge University Press. All rights reserved.
Authors & Co-Authors
Smith, Thomas A.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Lehmann, Deborah
South Africa
Papua new Guinea Institute of Medical Research
Montgomery, Janet M.
Australia, Brisbane
Mater Health Services Brisbane
Gratten, Michael J.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Riley, Ian Douglas
Australia, Brisbane
The University of Queensland
Alpers, Michael Philip
South Africa
Papua new Guinea Institute of Medical Research
Statistics
Citations: 138
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1017/S0950268800056648
ISSN:
09502688
e-ISSN:
14694409
Research Areas
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Guinea