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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Whole-body MRI in the diagnosis of paediatric CNO/CRMO
Rheumatology (United Kingdom), Volume 59, No. 10, Year 2020
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Description
Chronic recurrent multifocal osteomyelitis (CRMO) is an auto-inflammatory disorder affecting the skeleton of children and adolescents. Whole-body MRI (WBMRI) is key in the diagnosis and follow-up of CRMO. Imaging protocols should include sagittal short Tau inversion recovery of the spine, imaging of the hands and feet, and T1 images for distinguishing normal bone marrow. CRMO lesions can be metaphyseal, epiphyseal and physeal - potentially causing growth disturbance and deformity. Spinal lesions are common, important and can cause vertebral collapse. Lesion patterns include multifocal tibial and pauci-focal patterns that follow a predictable presentation and course of disease. Common pitfalls of WBMRI include haematopoietic marrow signal, metaphyseal signal early on in bisphosphonate therapy and normal high T2 signal in the hands and feet. Pictorial reporting assists in recording lesions and follow-up over time. The purpose of this paper is to review the different WBMRI protocols, imaging findings, lesion patterns and common pitfalls in children with CRMO © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Authors & Co-Authors
Andronikou, Savvas K.D.
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
University of Pennsylvania
Offiah, Amaka C.
United Kingdom, Sheffield
Sheffield Children's Nhs Foundation Trust
Douis, Hassan
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Barrera, Christian A.
United States, Philadelphia
The Children's Hospital of Philadelphia
Ramanan, Athimalaipet Vaidyanathan
United Kingdom, Bristol
Bristol Royal Hospital for Children
United Kingdom, Bristol
University of Bristol
Statistics
Citations: 27
Authors: 5
Affiliations: 10
Identifiers
Doi:
10.1093/rheumatology/keaa303
ISSN:
14620324
Research Areas
Maternal And Child Health
Study Design
Cohort Study