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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Ambient particulate matter affects cardiac recovery in a Langendorff ischemia model
Inhalation Toxicology, Volume 18, No. 9, Year 2006
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Description
Exposure to ambient particulate matter (PM) is associated with increased mortality and morbidity among subjects with cardiovascular impairment. We hypothesized that exposure of spontaneously hypertensive (SH) rats to PM impairs the recovery of cardiovascular performance after coronary occlusion and reperfusion-ischemia. SH rats were exposed by intratracheal instillation to saline, standard urban PM (Ottawa dust EHC-93, 10 mg/kg body weight) or endotoxin (lipopolysaccharides LPS, 350 EU/animal) to induce a similar pulmonary inflammation. At 4 h postexposure, hearts were isolated and retrograde perfused in a Langendorff model. The experimental protocol included 35 min of coronary occlusion followed by 120 min of reperfusion, during which left ventricular developing pressure (LDVP), coronary flow (CF), and heart rate (HR) were measured. Baseline LVDP in particle-instilled SH rats was significantly decreased compared to saline-instilled animals. In addition, after ischemia the recovery of LDVP was much slower in rats pretreated with PM or LPS compared to saline instilled rats. The direct effects of the soluble PM fraction and the role of Zn 2+ were also tested cardiomyocytes (H9C2 cells). Both particle-free filtrate and Zn 2+ inhibited ATP or ionophore-stimulated calcium influx in cardiomyocytes. This inhibitory effect was related to an effect on calcium channels, as shown with Nifedipine. This study provides evidence that exposure to instillation of PM has reversible acute effects on the recovery of cardiac physiological parameters after ischemia. The effect may be caused by a direct action of soluble metals on calcium homeostasis in heart, but pulmonary inflammation may also play a significant role. Copyright © Taylor and Francis Group, LLC.
Authors & Co-Authors
Bagate, Karim
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Cote D'ivoire, Abidjan
University of Abobo-adajmé
Meiring, James
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Gerlofs-Nijland, Miriam
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Cassee, Flemming
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Wiegand, Herbert
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Osornio-Vargas, Alvaro
Mexico, Tlalpan
Instituto Nacional de Cancerologia, México
Borm, Paul
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Netherlands, Heerlen
Center of Expertise in Life Sciences
Netherlands, Maastricht
Zuyd Hogeschool
Statistics
Citations: 7
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1080/08958370600742706
ISSN:
08958378
e-ISSN:
10917691
Research Areas
Noncommunicable Diseases