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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Acetaminophen and aspirin inhibit superoxide anion generation and lipid peroxidation, and protect against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats
Neurochemistry International, Volume 44, No. 5, Year 2004
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Description
We assessed the antioxidant activity of non-narcotic analgesics, acetaminophen and aspirin in rat brain homogenates and neuroprotective effects in vivo in rats intranigrally treated with 1-methyl-4-phenyl pyridinium (MPP+). Both drugs inhibited cyanide-induced superoxide anion generation, as well as lipid peroxidation in rat brain homogenates, the combination of the agents resulting in a potentiation of this effect. Acetaminophen or aspirin when administered alone or in combination, did not alter dopamine (DA) levels in the forebrain or in the striatum. Intranigral infusion of MPP+ in rats caused severe depletion of striatal DA levels in the ipsilateral striatum in rats by the third day. Systemic post-treatment of acetaminophen afforded partial protection, whereas similar treatment of aspirin resulted in complete blockade of MPP+-induced striatal DA depletion. While these findings suggest usefulness of non-narcotic analgesics in neuroprotective therapy in neurodegenerative diseases, aspirin appears to be a potential candidate in prophylactic as well as in adjuvant therapy in Parkinson's disease. © 2003 Published by Elsevier Ltd.
Authors & Co-Authors
Maharaj, Deepa S.
South Africa, Grahamstown
Rhodes University
Saravanan, Karuppagounder S.
India, Kolkata
Indian Institute of Chemical Biology
Maharaj, Himant
South Africa, Grahamstown
Rhodes University
Mohanakumar, K. P.
India, Kolkata
Indian Institute of Chemical Biology
Daya, Santy
South Africa, Grahamstown
Rhodes University
Statistics
Citations: 85
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/S0197-0186(03)00170-0
ISSN:
01970186