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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF
Journal of the American Heart Association, Volume 5, No. 3, Article e002197, Year 2015
Notification
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Description
Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intentionto- treat population. The median age was 73 years, and the mean CHADS2 score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P<0.0001) and age ≥75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P<0.0001) were associated with higher all-cause mortality. Multiple additional characteristics were independently associated with higher mortality, with decreasing creatinine clearance, chronic obstructive pulmonary disease, male sex, peripheral vascular disease, and diabetes being among the most strongly associated (model C-index 0.677). Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, ≈7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival. © 2016 The Authors.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4943233/bin/JAH3-5-e002197-s001.pdf
Authors & Co-Authors
Pokorney, Sean D.
United States, Durham
Duke Clinical Research Institute
Piccini, Jonathan Paul
United States, Durham
Duke Clinical Research Institute
Stevens, Susanna R.
United States, Durham
Duke Clinical Research Institute
Patel, Manesh Raman
United States, Durham
Duke Clinical Research Institute
Pieper, Karen S.
United States, Durham
Duke Clinical Research Institute
Halperin, Jonathan Lee
United States, New York
The Mount Sinai Medical Center
Breithardt, Gu¨nter E.
Germany, Munster
University of Münster
Hankey, Graeme J.
Australia, Perth
Royal Perth Hospital
Berkowitz, Scott D.
United States, Whippany
Bayer Corporation, Usa
Mahaffey, Kenneth W.
United States, Palo Alto
Stanford University
Fox, Keith A.A.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Califf, Robert M.
United States, Durham
Duke University
Sundaram, Sri
Unknown Affiliation
Banerjee, Subhash
Unknown Affiliation
French, William J.
Unknown Affiliation
Chandrashekhar, Y. S.
Unknown Affiliation
Shah, Sanjiv Jayendra
Unknown Affiliation
Haldis, Thomas A.
Unknown Affiliation
Koreň, Michael J.
Unknown Affiliation
White, Jennifer A.
Unknown Affiliation
Chappel, Christopher M.
Unknown Affiliation
Howard, Virginia J.
Unknown Affiliation
Corbelli, John C.
Unknown Affiliation
Hutchinson, Barbara A.
Unknown Affiliation
Khera, Amit
Unknown Affiliation
Go, Alan S.
Unknown Affiliation
Thomas, Gregory S.
Unknown Affiliation
Zimetbaum, Peter J.
Unknown Affiliation
Hunter, John J.
Unknown Affiliation
Barbarash, Olga Leonidovna
Unknown Affiliation
Tereschenko, Sergey N.
Unknown Affiliation
Baranova, Ekaterina Vitalievna
Unknown Affiliation
Kuznetsov, Vadim Anatolyevich
Unknown Affiliation
Kouz, Simon M.
Unknown Affiliation
Ma, Patrick T.S.
Unknown Affiliation
Senior, Roxy
Unknown Affiliation
Bell, Alan David
Unknown Affiliation
Tellier, Guy
Unknown Affiliation
O'Mahony, Marcella Sinead
Unknown Affiliation
Ng, Kelvin Kuan Huei
Unknown Affiliation
Cheung, Matthew
Unknown Affiliation
Bernstein, Inge Thomsen
Unknown Affiliation
Khurana, Mona
Unknown Affiliation
Ebrahim, Iftikhar Osman
Unknown Affiliation
van Zyl, Louis T.
Unknown Affiliation
Theron, Hendrik Du Toit
Unknown Affiliation
Podgorski, Gracjan P.
Unknown Affiliation
Steingo, Leonard
Unknown Affiliation
Dalby, Anthony John
Unknown Affiliation
Bayat, Junaid
Unknown Affiliation
Herbst, Larissa
Unknown Affiliation
Bester, Frederik C.J.
Unknown Affiliation
Bennett, James R.
Unknown Affiliation
Abelson, Mark
Unknown Affiliation
Nortje, Hendrik F.M.
Unknown Affiliation
Manolis, Athanasios John
Unknown Affiliation
Basart, Dick C.G.
Unknown Affiliation
Crijns, Harry JGM
Unknown Affiliation
van Gelder, Isabelle C.
Unknown Affiliation
Groutars, Reginald G.E.J.
Unknown Affiliation
Kragten, Hans A.
Unknown Affiliation
Heidbuchel, H.
Unknown Affiliation
Goethals, Marnix P.N.
Unknown Affiliation
Galinier, Michel C.
Unknown Affiliation
Steg, Philippe Gabriel
Unknown Affiliation
Iñíguez, Carmen
Unknown Affiliation
Calvo-Iglesias, Francisco E.
Unknown Affiliation
Merino, José Luis
Unknown Affiliation
Martinez-Rubio, A.
Unknown Affiliation
Gónzalez-Juanatey, José Ramón
Unknown Affiliation
Jánosi, András
Unknown Affiliation
Dániel, Bereczki
Unknown Affiliation
Kiss, Róbert Gábor
Unknown Affiliation
Diószeghy, Péter
Unknown Affiliation
Terrosu, Pierfranco
Unknown Affiliation
Cosmi, Francesco
Unknown Affiliation
Salvioni, Alessandro
Unknown Affiliation
Boriani, Giuseppe
Unknown Affiliation
Calvi, Valeria Ilia
Unknown Affiliation
De Caterina, Raffaele
Unknown Affiliation
Parati, Gianfranco
Unknown Affiliation
Di Biase, Matteo
Unknown Affiliation
Fattore, Luciano
Unknown Affiliation
Agnelli, Giancarlo
Unknown Affiliation
Merlini, Piera Angelica
Unknown Affiliation
Ageno, Walter
Unknown Affiliation
Cintezǎ, Mircea A.
Unknown Affiliation
Tatu-Chiţoiu, Gabriel Petrisor
Unknown Affiliation
Drãgulescu, Ştefan Iosif
Unknown Affiliation
Militaru, Constantin
Unknown Affiliation
Pirvu, Octavian
Unknown Affiliation
Vinereanu, Dragoș
Unknown Affiliation
Janota, Tomáš
Unknown Affiliation
Linhart, Aleš
Unknown Affiliation
Ošťǎdal, Petr
Unknown Affiliation
Polášek, Rostislav
Unknown Affiliation
Huber, Kurt H.
Unknown Affiliation
Drexel, Heinz
Unknown Affiliation
Brainin, Michael
Unknown Affiliation
Lang, Wielfried
Unknown Affiliation
Moriarty, Andrew J.
Unknown Affiliation
Cleland, John G.F.
Unknown Affiliation
MacWalter, Ronald S.M.
Unknown Affiliation
Cooke, John P.
Unknown Affiliation
McInnes, Gordon T.
Unknown Affiliation
Durairaj, Ramesh
Unknown Affiliation
MacLeod, Mary Joan
Unknown Affiliation
Lip, Gregory Y.H.
Unknown Affiliation
MacLeod, Malcolm Robert
Unknown Affiliation
Roffe, Christine
Unknown Affiliation
Bath, Philip M.
Unknown Affiliation
Stender, Steen
Unknown Affiliation
Blomström, Per
Unknown Affiliation
Kjærnli, Thorbjørn
Unknown Affiliation
Łoboz-Grudzień, Krystyna
Unknown Affiliation
Rynkiewicz, Andrzej
Unknown Affiliation
Chojnowska, Lidia S.
Unknown Affiliation
Tendera, Michal B.
Unknown Affiliation
Gaciong, Zbigniew A.
Unknown Affiliation
Krzeminśka-Pakuła, Maria
Unknown Affiliation
Brachmann, Johannes
Unknown Affiliation
Bode, Christoph
Unknown Affiliation
Darius, Harald
Unknown Affiliation
Vom Dahl, Juergen V.
Unknown Affiliation
Kraemer, Alexander
Unknown Affiliation
Veltkamp, Roland C.
Unknown Affiliation
Winkelmann, Bernhard Rudolf
Unknown Affiliation
Bernhardt, Peter
Unknown Affiliation
Kadel, Christoph
Unknown Affiliation
Seidl, Karlheinz F.
Unknown Affiliation
Schellong, Sebastian M.
Unknown Affiliation
Guevara, Carolina
Unknown Affiliation
Medina, Félix A.
Unknown Affiliation
Leiva-Pons, José Luís
Unknown Affiliation
Alcocer-Gamba, Marco Antonio
Unknown Affiliation
Cuneo, Carlos Alberto
Unknown Affiliation
Hominal, Miguel Angel
Unknown Affiliation
Lúquez, Hugo A.
Unknown Affiliation
Montaña, Oscar R.
Unknown Affiliation
Teixidor, Jordi Teixidor
Unknown Affiliation
Vita, Néstor Alejandro
Unknown Affiliation
MacKinnon, Ignacio J.
Unknown Affiliation
Casabe´, José Horacio
Unknown Affiliation
Lobo Márquez, Lilia Luz Del Valle
Unknown Affiliation
Cuadrado, Jesus A.
Unknown Affiliation
Dran, Ricardo Dario
Unknown Affiliation
Cartasegna, Luis Rodolfo
Unknown Affiliation
Hasbani, Eduardo G.
Unknown Affiliation
Hrabar, Adrián D.
Unknown Affiliation
Vogel, Daniel R.
Unknown Affiliation
Hershson, Alejandro Rubén
Unknown Affiliation
Avezum, Álvaro Jr
Unknown Affiliation
Maia, Lília Nigro
Unknown Affiliation
Manenti, Euler Roberto Fernandes
Unknown Affiliation
Précoma, Dalton Bertolim
Unknown Affiliation
Zimerman, Leandro Ioschpe
Unknown Affiliation
Teixeira, Marcelo Silveira
Unknown Affiliation
Reis, Gilmar
Unknown Affiliation
Zimmermann, Sergio Luiz
Unknown Affiliation
Rossi Dos Santos, Fabio
Unknown Affiliation
Lanas, Fernando T.
Unknown Affiliation
Olivares, Claudia
Unknown Affiliation
Urina-Triana, Miguel
Unknown Affiliation
Morr, Igor
Unknown Affiliation
Basri, Hamidon
Unknown Affiliation
Thompson, Peter Lindsay
Unknown Affiliation
Heddle, Bill
Unknown Affiliation
Walters, Darren L.
Unknown Affiliation
Amerena, John V.
Unknown Affiliation
Parsons, Mark W.
Unknown Affiliation
Phan, Thanh G.
Unknown Affiliation
Bladin, Christopher F.
Unknown Affiliation
Donnan, Geoffrey Alan
Unknown Affiliation
Anderson, Craig S.
Unknown Affiliation
Cross, David B.
Unknown Affiliation
Richards, Arthur Mark
Unknown Affiliation
Singh, Rajvir R.
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Sukonthasarn, Apichard
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Tanomsup, Supachai
Unknown Affiliation
Krittayaphong, Rungroj
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Chung, Namsik
Unknown Affiliation
Kim, Chongjin
Unknown Affiliation
Yan, Xiaowei
Unknown Affiliation
Fu, Guosheng
Unknown Affiliation
Xu, Dongjie
Unknown Affiliation
Chen, Jessie Ze Jun
Unknown Affiliation
Yin, Yuehui
Unknown Affiliation
Zhao, Yusheng
Unknown Affiliation
Hu, Dayi
Unknown Affiliation
Ma, Changsheng
Unknown Affiliation
Sun, Jie Lena
Unknown Affiliation
Li, Ya Huei
Unknown Affiliation
Wang, Yong
Unknown Affiliation
Chen, K. N.
Unknown Affiliation
Wang, Hao
Unknown Affiliation
Chen, Yingmin
Unknown Affiliation
Kozan, Ömer
Unknown Affiliation
Altunkeser, Bülent Behlül
Unknown Affiliation
Janorkar, Satej
Unknown Affiliation
Panwar, Rajababoo Babu
Unknown Affiliation
Kaste, Markku
Unknown Affiliation
Raev, Dimitar H.
Unknown Affiliation
Kavoliūnienė, Aušra
Unknown Affiliation
Sirenko, Yu M.
Unknown Affiliation
Tse, Hung Fat
Unknown Affiliation
Yu, Chuanhua
Unknown Affiliation
Wong, Lawrence Ka Sing
Unknown Affiliation
Yeh, Huei-Ming
Unknown Affiliation
Hsieh, I. Chang
Unknown Affiliation
Huang, Christopher L.H.
Unknown Affiliation
Yin, Weihsian
Unknown Affiliation
Chiang, Fu Tien
Unknown Affiliation
Ueng, Kwo Chiang
Unknown Affiliation
Charng, Mingji
Unknown Affiliation
Yeh, Hung I.
Unknown Affiliation
Lewis, Basil S.
Unknown Affiliation
Eldar, Michael
Unknown Affiliation
Zimlíchman, Reuven R.
Unknown Affiliation
Nseir, William B.
Unknown Affiliation
Statistics
Citations: 127
Authors: 219
Affiliations: 11
Identifiers
Doi:
10.1161/JAHA.115.002197
ISSN:
20479980
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Participants Gender
Male