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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding
Cell Reports, Volume 36, No. 5, Article 109493, Year 2021
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Description
Safe and effective vaccines are urgently needed to stop the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a series of live attenuated vaccine candidates by large-scale recoding of the SARS-CoV-2 genome and assess their safety and efficacy in Syrian hamsters. Animals were vaccinated with a single dose of the respective recoded virus and challenged 21 days later. Two of the tested viruses do not cause clinical symptoms but are highly immunogenic and induce strong protective immunity. Attenuated viruses replicate efficiently in the upper but not in the lower airways, causing only mild pulmonary histopathology. After challenge, hamsters develop no signs of disease and rapidly clear challenge virus: at no time could infectious virus be recovered from the lungs of infected animals. The ease with which attenuated virus candidates can be produced and administered favors their further development as vaccines to combat the ongoing pandemic. © 2021 The Authors
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8289629/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8289629/bin/mmc2.pdf
Authors & Co-Authors
Trimpert, Jakob
Germany, Berlin
Freie Universität Berlin
Dietert, Kristina
Germany, Berlin
Freie Universität Berlin
Firsching, Theresa C.
Germany, Berlin
Freie Universität Berlin
Vladimirova, Daria
Germany, Berlin
Freie Universität Berlin
Labroussaa, Fabien
Switzerland, Zurich
Vetsuisse-fakultät
Abdelgawad, Azza
Germany, Berlin
Freie Universität Berlin
Conradie, Andelé Marie
Germany, Berlin
Freie Universität Berlin
Adler, Julia Maria
Germany, Berlin
Freie Universität Berlin
Bertzbach, Luca D.
Germany, Berlin
Freie Universität Berlin
Jores, Joerg
Switzerland, Zurich
Vetsuisse-fakultät
Gruber, Achim D.
Germany, Berlin
Freie Universität Berlin
Thiel, Volker
Switzerland, Mittelhausen
Institut Für Viruskrankheiten Und Immunprophylaxe
Switzerland, Zurich
Vetsuisse-fakultät
Kunec, Dušan
Germany, Berlin
Freie Universität Berlin
Statistics
Citations: 42
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1016/j.celrep.2021.109493
ISSN:
22111247
Research Areas
Covid