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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Combined multiphoton imaging-pixel analysis for semiquantitation of skin penetration of gold nanoparticles
International Journal of Pharmaceutics, Volume 413, No. 1-2, Year 2011
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Description
Interaction of nanoparticles with the skin barrier is a recent area of research that draws a lot of attention from the researchers. However, monitoring nanoparticles in or through the skin is mainly based on qualitative microscopical techniques. Yet, a quantitative approach is required for a better basic understanding. In response, a combined "multiphoton-pixel analysis" method was developed in this study for semiquantitation of gold nanoparticles penetration into different skin layers. The developed approach provides a useful tool for future studies focusing on skin penetration of nanoparticles for the aim of health risk assessment or for the design of topical and transdermal drug delivery systems. © 2011 Elsevier B.V. All Rights Reserved.
Authors & Co-Authors
Labouta, Hagar Ibrahim
Germany, Saarbrucken
Universität Des Saarlandes
Egypt, Alexandria
Faculty of Pharmacy
Kraus, Tobias
Germany, Saarbrucken
Leibniz Institute for new Materials
El-Khordagui, Labiba Khalil
Egypt, Alexandria
Faculty of Pharmacy
Schneider, Marc
Germany, Saarbrucken
Universität Des Saarlandes
Statistics
Citations: 56
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.ijpharm.2011.03.067
ISSN:
03785173
e-ISSN:
18733476
Study Approach
Qualitative
Quantitative