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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Immunity in human schistosomiasis mansoni: Prevention by blocking antibodies of the expression of immunity in young children
Parasitology, Volume 94, No. 2, Year 1987
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Description
A total of 129 children were treated for Schistosoma mansoni infections, and followed for intensity of reinfection at 3-monthly intervals over a 21-month period. Blood samples were taken before treatment and at 5 weeks and 6, 12 and 18 months after treatment. This paper presents a statistical analysis of the relationship between various immune responses and subsequent reinfection. Responses analysed were: blood eosinophil levels; IgE antibodies against schistosomulum antigens; IgG antibodies mediating eosinophil-dependent killing of schistosomula; antibodies inhibiting the binding to schistosomulum antigens of two rat monoclonal antibodies that also recognize egg antigens; the levels of anti-adult worm and of anti-egg (total, IgM and IgG) antibodies; and IgM anti-schistosomulum antibodies. Results for each assay were well correlated for each of the five separate blood samples. None of the assays were predictive of resistance to reinfection, but susceptibility to reinfection was strongly correlated with results in the preceding blood samples for total anti-egg antibodies and the inhibition of binding of one of the two monoclonal antibodies. Further analysis also revealed a correlation between reinfection intensities and both IgM anti-schistosomulum antibodies and IgM and IgG anti-egg antibodies. These results are consistent with the hypothesis that early infections elicit the development, in response to egg antigens, of antibodies that block immune mechanisms directed against schistosomula. Blocking antibodies may be IgM, but might also be of an ineffective IgG isotype. The existence of such antibodies in young children would explain the slow development of immunity in the face of a range of detectable, potentially protective immune responses. © 1987, Cambridge University Press. All rights reserved.
Authors & Co-Authors
Butterworth, Anthony E.
Unknown Affiliation
Dunne, David William
Unknown Affiliation
Bensted-Smith, R.
Unknown Affiliation
Caprón, André R.
Unknown Affiliation
Capron, Monique
Unknown Affiliation
Grzych, Jean Marie
Unknown Affiliation
Khalife, Jamal
Unknown Affiliation
Dalton, P. R.
Unknown Affiliation
Kariuki, Henry Curtis
Unknown Affiliation
Ouma, John Henry
Unknown Affiliation
Koech, David Kiprotich
Unknown Affiliation
Mugambi, Mutama
Unknown Affiliation
Siongok, Timothy Karap
Unknown Affiliation
Sturrock, Robert F.
Unknown Affiliation
Statistics
Citations: 133
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1017/S0031182000053956
e-ISSN:
14698161
Research Areas
Infectious Diseases
Maternal And Child Health
Study Approach
Quantitative