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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Trends and determining factors associated with adherence to antiretroviral therapy (ART) in Cameroon: A systematic review and analysis of the CAMPS trial
AIDS Research and Therapy, Volume 9, Article 37, Year 2012
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Description
Background: The benefits of antiretroviral therapy (ART) cannot be experienced if they are not taken as prescribed. Yet, not all causes of non-adherence are dependent on the patient. Having to pay for medication reduces adherence rates. Non- adherence has severe public health implications which must be addressed locally and globally. This paper seeks to describe the trends in adherence rates reported in Cameroon and to investigate the determinants of adherence to ART in the Cameroon Mobile Phone SMS (CAMPS) trial.Methods: We conducted a systematic review of electronic databases (PubMed, Google Scholar, Web of Science, CINAHL, EMBASE and PSYCINFO) for publications on adherence to ART in Cameroon (from January 1999 to May 2012) and described the trend in reported adherence rates and the factors associated with adherence. Data were extracted in duplicate. We used multivariable analyses on the baseline data for 200 participants in the CAMPS trial to determine the factors associated with adherence in four models using different measures of adherence (more than 90% or 95% on the visual analogue scale, no missed doses and a composite measure: 100% on the visual analogue scale, no missed doses and all pills taken on time).Results: We identified nine studies meeting our inclusion criteria. Adherence to ART in Cameroon has risen steadily between 2000 and 2010, corresponding to reductions in the cost of medication. The factors associated with adherence to ART in Cameroon are grouped into patient, medication and disease related factors. We also identified factors related to the health system and the patient-provider relationship. In the CAMPS trial, education, side effects experienced and number of reminder methods were found to improve adherence, but only using multiple reminder methods was associated with better adherence in all the regression models (Adjusted Odds Ratio [AOR] 4.11, 95% Confidence Interval [CI] 1.89, 8.93; p<0.001; model IV).Conclusions: Reducing the cost of ART is an important aspect of ensuring adequate adherence rates. Using multiple reminder methods may have a cumulative effect on adherence to ART, but should be investigated further. © 2012 Mbuagbaw et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Mbuagbaw, Lawrence C.E.
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Canada, Hamilton
Mcmaster University
Thabane, Lehana
Canada, Hamilton
Mcmaster University
Canada, Hamilton
St. Joseph's Healthcare Hamilton
Ongolo-Zogo, Pierre
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Yondo, David
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Noorduyn, Stephen
Canada, Hamilton
Mcmaster University
Smieja, Marek J.
Canada, Hamilton
Mcmaster University
Canada, Hamilton
St. Joseph's Healthcare Hamilton
Dolovich, Lisa R.
Canada, Hamilton
Mcmaster University
Statistics
Citations: 27
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1186/1742-6405-9-37
e-ISSN:
17426405
Research Areas
Health System And Policy
Study Design
Case-Control Study
Study Approach
Systematic review
Study Locations
Cameroon