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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting
Ticks and Tick-borne Diseases, Volume 3, No. 3, Year 2012
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Description
Commercial vaccines based on the tick gut protein Bm86 have been successful in controlling the one-host tick . Rhipicephalus (Boophilus) microplus and provide heterologous protection against certain other non-target ixodid tick species. This cross protection, however, does not extend to the three-host tick . R. appendiculatus, the vector of the protozoan parasite . Theileria parva. When transmitted to cattle, . T. parva causes the often fatal disease East Coast fever. Here, we used insect cell-expressed recombinant versions of the . R. appendiculatus homologs of Bm86, named Ra86, to vaccinate cattle. We measured multiple fitness characteristics for ticks that were fed on cattle Ra86-vaccinated or unvaccinated. The Ra86 vaccination of cattle significantly decreased the molting success of nymphal ticks to the adult stage. Modeling simulations based on our empirical data suggest that repeated vaccinations using Ra86 could reduce tick populations over successive generations. Vaccination with Ra86 could thus form a component of integrated control strategies for . R. appendiculatus leading to a reduction in use of environmentally damaging acaricides. © 2012 Elsevier GmbH.
Authors & Co-Authors
Olds, Cassandra L.
Unknown Affiliation
Mwaura, Stephen N.
Unknown Affiliation
Crowder, David
Unknown Affiliation
Odongo, David Otieno
Unknown Affiliation
Van Oers, Monique M.
Unknown Affiliation
Owen, Jeb
Unknown Affiliation
Bishop, Richard Peter
Unknown Affiliation
Daubenberger, Claudia Andrea
Unknown Affiliation
Statistics
Citations: 16
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1016/j.ttbdis.2012.03.003
ISSN:
1877959X
e-ISSN:
18779603
Research Areas
Maternal And Child Health