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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Human TLR-7-, -8-, and -9-mediated induction of IFN-α/β and -λ Is IRAK-4 dependent and redundant for protective immunity to viruses
Immunity, Volume 23, No. 5, Year 2005
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Description
Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-α/β and -λ. Surprisingly, patients with a defect of IRAK-4, a critical kinase downstream from TLRs, are resistant to common viruses. We show here that IFN-α/β and -λ induction via TLR-7, TLR-8, and TLR-9 was abolished in IRAK-4-deficient blood cells. In contrast, IFN-α/β and -λ were induced normally by TLR-3 and TLR-4 agonists. Moreover, IFN-β and -λ were normally induced by TLR-3 agonists and viruses in IRAK-4-deficient fibroblasts. We further show that IFN-α/β and -λ production in response to 9 of 11 viruses tested was normal or weakly affected in IRAK-4-deficient blood cells. Thus, IRAK-4-deficient patients may control viral infections by TLR-3- and TLR-4-dependent and/or TLR-independent production of IFNs. The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-α/β and -λ is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans. ©2005 by Elsevier Inc.
Authors & Co-Authors
Yang, Kun
France, Paris
L'institut Des Maladies Génétiques Imagine
China, Shanghai
Shanghai Jiao Tong University School of Medicine
Puel, Anne
France, Paris
L'institut Des Maladies Génétiques Imagine
Zhang, Shenying
France, Paris
L'institut Des Maladies Génétiques Imagine
China, Shanghai
Shanghai Jiao Tong University School of Medicine
Eidenschenk, Céline
France, Paris
L'institut Des Maladies Génétiques Imagine
Ku, Cheng-Lung
France, Paris
L'institut Des Maladies Génétiques Imagine
Casrouge, Armanda
France, Paris
L'institut Des Maladies Génétiques Imagine
Pïcard, Capucine
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Hôpital Necker Enfants Malades
von Bernuth, Horst
France, Paris
L'institut Des Maladies Génétiques Imagine
Senechal, Brigitte
France, Paris
Hôpital Necker Enfants Malades
Plancoulaine, Sabine
France, Paris
L'institut Des Maladies Génétiques Imagine
Al-Hajjar, Sami Hussain
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Ghonaium, Abdulaziz
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Máródi, László D.R.
Hungary, Debrecen
Általános Orvostudományi Kar
Davidson, Donald
Canada, Vancouver
Bc Children's Hospital Research Institute
Speert, David Paul
Canada, Vancouver
Bc Children's Hospital Research Institute
Roifman, Chaim M.
Canada, Toronto
Hospital for Sick Children University of Toronto
Garty, Ben Zion
Israel, Petah Tiqwa
Schneider Childrens Medical Center Israel
Ozinsky, Adrian
United States, Seattle
Institute for Systems Biology
Barrat, Franck J.
United States, Berkeley
Dynavax Technologies Corporation
Coffman, Robert L.
United States, Berkeley
Dynavax Technologies Corporation
Miller, Richard L.
United States, Saint Paul
3m Usa
Li, Xiaoxia
United States, Cleveland
Cleveland Clinic Foundation
Lebon, Pierre
France, Paris
Hopital Saint-vincent-de-paul
Rodríguez-Gallego, Carlos
Spain, Las Palmas de Gran Canaria
Hospital de Gran Canaria Dr. Negrin
Chapel, Helen M.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Geissmann, Frédéric
France, Paris
Hôpital Necker Enfants Malades
Jouanguy, Emmanuelle
France, Paris
L'institut Des Maladies Génétiques Imagine
China, Shanghai
Shanghai Jiao Tong University School of Medicine
Casanova, Jean Laurent
France, Paris
L'institut Des Maladies Génétiques Imagine
China, Shanghai
Shanghai Jiao Tong University School of Medicine
France, Paris
Hôpital Necker Enfants Malades
Statistics
Citations: 267
Authors: 28
Affiliations: 15
Identifiers
Doi:
10.1016/j.immuni.2005.09.016
ISSN:
10747613