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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Estimating and Mapping the Population at Risk of Sleeping Sickness
PLoS Neglected Tropical Diseases, Volume 6, No. 10, Article e1859, Year 2012
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Description
Background: Human African trypanosomiasis (HAT), also known as sleeping sickness, persists as a public health problem in several sub-Saharan countries. Evidence-based, spatially explicit estimates of population at risk are needed to inform planning and implementation of field interventions, monitor disease trends, raise awareness and support advocacy. Comprehensive, geo-referenced epidemiological records from HAT-affected countries were combined with human population layers to map five categories of risk, ranging from "very high" to "very low," and to estimate the corresponding at-risk population. Results: Approximately 70 million people distributed over a surface of 1.55 million km2 are estimated to be at different levels of risk of contracting HAT. Trypanosoma brucei gambiense accounts for 82.2% of the population at risk, the remaining 17.8% being at risk of infection from T. b. rhodesiense. Twenty-one million people live in areas classified as moderate to very high risk, where more than 1 HAT case per 10,000 inhabitants per annum is reported. Discussion: Updated estimates of the population at risk of sleeping sickness were made, based on quantitative information on the reported cases and the geographic distribution of human population. Due to substantial methodological differences, it is not possible to make direct comparisons with previous figures for at-risk population. By contrast, it will be possible to explore trends in the future. The presented maps of different HAT risk levels will help to develop site-specific strategies for control and surveillance, and to monitor progress achieved by ongoing efforts aimed at the elimination of sleeping sickness. © 2012 World Health Organization.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3493382/bin/pntd.0001859.s001.pdf
Authors & Co-Authors
Simarro, Pere P.
Switzerland, Geneva
Organisation Mondiale de la Santé
Cecchi, Giuliano
Italy, Rome
Food and Agriculture Organization of the United Nations
Franco, José Ramón
Switzerland, Geneva
Organisation Mondiale de la Santé
Paone, Massimo
Italy, Rome
Food and Agriculture Organization of the United Nations
Diarra, Abdoulaye
Congo, Brazzaville
World Health Organization Regional Office for Africa Congo
Ruiz-Postigo, José Antonio
Switzerland, Geneva
Organisation Mondiale de la Santé
Fèvre, Eric Maurice
United Kingdom, Edinburgh
The University of Edinburgh
Mattioli, Raffaele C.
Italy, Rome
Food and Agriculture Organization of the United Nations
Jannin, Jean G.
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 326
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pntd.0001859
ISSN:
19352735
Study Design
Cross Sectional Study
Study Approach
Quantitative