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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Metabolic bone disease in black teenagers with genu valgum or varum without radiologic rickets: A bone histomorphometric study
Journal of Bone and Mineral Research, Volume 9, No. 4, Year 1994
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Description
Calcium deficiency in black (African) children can cause rickets and osteomalacia with severe limb deformities. It is not known whether black teenagers with genu valgum or varum but without radiologic rickets suffer from a related disorder. To examine this question we studied 26 such patients by iliac crest bone biopsy and serum and urine biochemistry: 12 patients (46%) had osteopenia with normal or low bone turnover, 5 (19%) mildly increased bone turnover, 4 (15%) histologic hyperparathyroidism, 2 (8%) preosteomalacia, and 3 (12%) osteomalacia (with features of hyperparathyroidism). Radiographs did not reflect the severity of the bone disease. Serum calcium levels correlated inversely with eroded mineralized surface (p < 0.001), osteoid surface (p < 0.01), osteoid thickness (p < 0.001), mineralization lag time (p < 0.001), and 1,25‐(OH)2 vitamin D (p < 0.005), and 1,25‐(OH)2 vitamin D correlated positively with osteoid surface (p < 0.05), osteoid thickness (p < 0.05), osteoid volume (p < 0.01), eroded surface (p < 0.05), and eroded mineralized surface (p < 0.0005). Tubular reabsorption of phosphate and 25‐OH vitamin D levels were normal, and 1,25‐(OH)2 vitamin D levels were normal to high. This suggests that calcium deficiency may have caused the increase in bone turnover and the mineralization defects. The most severe osteomalacia was found in males aged 16–19 years. We cannot explain the cause of the osteopenia. We conclude that all patients had bone disease. Copyright © 1994 ASBMR
Authors & Co-Authors
Schnitzler, Christine M.
South Africa, Johannesburg
University of the Witwatersrand
Pettifor, John M.
South Africa, Johannesburg
University of the Witwatersrand
Patel, Deepak N.
South Africa, Johannesburg
University of the Witwatersrand
Mesquita, Julia M.
South Africa, Johannesburg
University of the Witwatersrand
Moodley, Gopal P.
South Africa, Johannesburg
University of the Witwatersrand
Zachen, Dianne
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 6
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1002/jbmr.5650090407
ISSN:
08840431
e-ISSN:
15234681
Research Areas
Maternal And Child Health
Noncommunicable Diseases