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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Biphasic insulin aspart 30 treatment in patients with type 2 diabetes poorly controlled on prior diabetes treatment: Results from the PRESENT study
Current Medical Research and Opinion, Volume 24, No. 3, Year 2008
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Description
Aim: The safety and efficacy of biphasic insulin aspart (BIAsp30) were evaluated in patients uncontrolled on previous treatment (human insulin ± oral hypoglycaemic agent [OHA] or OHA only) in routine clinical practice. Methods: This was a large, multi-national, multicentre, prospective, 6-month study in type 2 diabetes mellitus patients who were prescribed BIAsp30. Changes in glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), postprandial plasma glucose (PPPG), proportion who achieved target HbA 1c < 7% and rate of hypoglycaemic episodes were assessed. This paper evaluates outcomes in patients by diabetes duration (< 5, 5-10, 10-20 or ≥ 20 years) stratified by prior therapy. Results: After 6 months of treatment, glycaemia improved significantly across the duration subgroups. The improvement was better in insulin-naïve group versus prior insulin group: HbA1c decreased ∼ 2.2%-points versus ∼ 1.6%-points, FPG decreased ∼ 4.5 mmol/L versus ∼ 2.9 mmol/L and PPPG decreased ∼ 6.8 mmol/L versus ∼ 5.0 mmol/L. Target HbA1c was achieved by about one in four patients although insulin-naïve patients achieved this at comparatively lower BIAsp30 dose. Body weight remained relatively unchanged. Hypoglycaemic episodes appeared to be more frequent in the prior insulin group which decreased during the treatment period. Conclusions: According to this observational study, in clinical practice, initiating or transferring uncontrolled patients to biphasic insulin aspart improved glycaemic control without using a strict insulin algorithm. © 2008 Librapharm Limited All rights reserved.
Authors & Co-Authors
Sharma, Surendra Kumar
India, Jaipur
Mg Medical College, Jaipur
al-Mustafa, M.
Iraq, Baghdad
National Diabetes Centre, Baghdad
Oh, Seungjoon
South Korea, Seoul
Kyung Hee Medical Center
Azar, Sami T.
Lebanon, Beirut
American University of Beirut
Shestakova, Marina V.
Russian Federation, Moscow
Institute of Diabetes
Güler, Serdar E.
Turkey, Ankara
Ankara Numune Education and Research Hospital
Vaz, Julius Anthony
Singapore, Singapore City
Novo Nordisk Pharma Singapore Pte Ltd
Statistics
Citations: 32
Authors: 7
Affiliations: 7
Identifiers
Doi:
10.1185/030079908X260952
ISSN:
03007995
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study