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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Differences in methylation on the active and inactive human X chromosomes
Annals of Human Genetics, Volume 49, No. 2, Year 1985
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Description
Methylation of CCGG sites was examined in four regions of the X chromosome with four X‐chromosome clones, three obtained by cloning random segments and one encoding a structural gene. In DNA from human peripheral blood cells unmethylated sites correlating with the inactive X chromosome were detected in the vicinity of two of the random clones and also in the vicinity of a cloned sequence of the X‐linked phosphoglycerate kinase gene (PGK). The third random clone covered a region whose methylation pattern was unchanged between the active and inactive X chromosomes. Differential methylation at the sites detected appears to have no functional role in the maintenance of the inactive X chromosome since both active and inactive X chromosomes were found to be undermethylated in DNA from human lymphoblastoid cells. Copyright © 1985, Wiley Blackwell. All rights reserved
Authors & Co-Authors
LINDSAY, S.
Mali, London
M.r.c. Mammalian Development Unit
MONK, M.
Mali, London
M.r.c. Mammalian Development Unit
HOLLIDAY, R.
United Kingdom, London
Mrc National Institute for Medical Research
Huschtscha, Lily Irene
United Kingdom, London
Mrc National Institute for Medical Research
Davies, K. E.
United Kingdom, Oxford
John Radcliffe Hospital
Riggs, Arthur D.
United States, Duarte
City of Hope National Med Center
Flavell, Richard A.
United States, Cambridge
Biogen Inc.
Statistics
Citations: 44
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1111/j.1469-1809.1985.tb01683.x
e-ISSN:
14691809
Research Areas
Genetics And Genomics