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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Necrotizing enterocolitis and high intestinal iron uptake due to genetic variants
Pediatric Research, Volume 83, No. 1, Year 2018
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Description
BackgroundIntestinal iron is a nutritional compound, which is essential for enteric microbiota. We evaluated the hypothesis that polymorphisms, which are known modifiers of intestinal iron uptake in adults, are associated with necrotizing enterocolitis (NEC) in preterm infants.MethodsPreterm infants (birth weight below 1,500 g) were studied. Single-nucleotide polymorphisms with known effects on serum iron levels (rs1800562, rs1799945, and rs855791) were determined using PCR. The effects of polymorphisms on NEC surgery were tested by Mendelian randomization. Outcome data were compared with ‡ 2 -test, Fisher's exact test, t-test, and Cochran-Armitage test for trend and multiple logistic regression analysis.ResultsComplete genotyping data were available for 11,166 infants. High serum iron levels due to rs855791 genotype were associated with a significantly reduced risk of NEC surgery (odds ratio (OR) 0.265; 95% confidence interval (CI) 0.11-0.65; adjusted P=0.011). Carriers of the rs855791 A-allele not receiving prophylactic probiotics had a higher risk of NEC surgery (OR 1.12, 95% CI 1.08-1.70, nominal P=0.002). Prophylactic treatment with probiotics was associated with a reduced risk of NEC surgery in carriers of the rs855791 A-Allele. No differences were found with regard to other short- or long-term outcome data.ConclusionPolymorphisms inducing lower intestinal iron uptake like the rs855791 A-allele might be an underestimated risk factor for NEC. © 2018 International Pediatric Research Foundation, Inc.
Authors & Co-Authors
Göpel, Wolfgang
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Rausch, Tanja Katrin
Germany, Lubeck
Universität zu Lübeck
Bohnhorst, Bettina
Germany, Hannover
Hannover Medical School
Müller, Andreas M.
Germany, Bonn
Universität Bonn
Franz, Axel Rainer
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Ziegler, Andreas E.
Germany, Lubeck
Statsol
Härtel, Christoph
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Herting, Egbert
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Statistics
Citations: 5
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1038/pr.2017.195
ISSN:
00313998
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Randomised Control Trial
Case-Control Study
Study Approach
Quantitative