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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of pap smear, visual inspection with acetic acid, human papillomavirus DNA-PCR testing and cervicography
International Journal of Gynecology and Obstetrics, Volume 89, No. 2, Year 2005
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Description
Objective: To assess the test qualities of four screening methods to detect cervical intra-epithelial neoplasia in an urban African setting. Method: Six hundred fifty-three women, attending a family planning clinic in Nairobi (Kenya), underwent four concurrent screening methods: pap smear, visual inspection with acetic acid (VIA), PCR for high risk human papillomavirus (HR HPV) and cervicography. The presence of cervical intra-epithelial neoplasia (CIN) was verified by colposcopy or biopsy. Result: Sensitivity (for CIN2 or higher) and specificity (to exclude any CIN or cancer) were 83.3% (95% CI [73.6, 93.0]) and 94.6% (95% CI [92.6, 96.5]), respectively, for pap smear; 73.3% (95% CI [61.8, 84.9]) and 80.0% (95% CI [76.6, 83.4]) for VIA; 94.4% (95% CI [84.6, 98.8]) and 73.9% (95% CI [69.7, 78.2]) for HR HPV; and 72.3% (95% CI [59.1, 85.6]) and 93.2% (95% CI [90.8, 95.7]) for cervicography. Conclusion: The pap smear had the highest specificity (94.6%) and HPV testing the highest sensitivity (94.4%). The visual methods, VIA and cervicography, were similar and showed an accuracy in between the former two tests. © 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
de Vuyst, Hugo
Belgium, Ghent
Universiteit Gent
Claeys, Patricia
Belgium, Ghent
Universiteit Gent
Njiru, S.
Kenya, Nairobi
University of Nairobi
Muchiri, Lucy Wangari
Kenya, Nairobi
University of Nairobi
Steyaert, S.
Belgium, Ghent
Universitair Ziekenhuis Gent
De Sutter, Philippe
Belgium, Brussels
Free Universities of Brussels
van Marck, Eric A.E.
Belgium, Edegem
Universitair Ziekenhuis Antwerpen
Bwayo, Job J.
Kenya, Nairobi
University of Nairobi
Temmerman, Marleen I.L.
Belgium, Ghent
Universiteit Gent
Statistics
Citations: 105
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.ijgo.2005.01.035
ISSN:
00207292
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Sexual And Reproductive Health
Study Locations
Kenya
Participants Gender
Female