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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mucosal humoral immune response to hepatitis C virus E1/E2 surface glycoproteins and HCV shedding in saliva and cervicovaginal fluids from chronically HCV-infected patients
Journal of Hepatology, Volume 38, No. 6, Year 2003
Notification
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Description
Background/Aims: We herein focused on identifying biological factors possibly involved in non-parenteral transmission of hepatitis C virus (HCV), such as HCV excretion patterns and antibody-based immunity to the virus in saliva and/or cervicovaginal secretions (CVS). Methods: Paired blood, saliva and cervicovaginal lavage samples were obtained from HCV-RNA plasma-positive hemoglobin (Hb) antigen and HIV-seronegative, HCV-seropositive males (n=13) and females (n=21). HCV-specific antibodies were detected by ELISA in paired samples, and HCV-RNA was detected in cell-free and cell-associated body fluids. Results: Antibodies to E1 HCV surface glycoprotein of the IgG and IgA isotypes showed similar, but less pronounced, profiles as IgG and IgA to E2. HCV-specific IgG and IgA in mucosal fluids likely originated predominantly from the systemic compartment, because HCV-specific mucosal immunoglobulins involved primarily monomeric antibodies, including monomeric IgA, and because their specific activities for HCV antigens in corporeal fluids were similar to those in paired serum (Se). Viral shedding in saliva or CVS was restricted to cell-associated, non-replicating strand(+) HCV-RNA in 42% (12 out of 28) of saliva and in 19% (four out of 21) of cervicovaginal fluids. Conclusions: The association in body fluids of HCV-specific IgG, and to a lesser extent IgA, directed to E1/E2 surface glycoproteins (which may block critical steps of virus-cell interactions), of undetectable free viral RNA, and of occasional non-replicating cell-associated HCV, suggests a resulting poor infectivity of saliva or cervicovaginal fluid in chronically HCV-infected individuals. Taken together, these observations provide the basis for the low risk of non-parenteral transmission of HCV infection. © 2003 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Bélec, Laurent
France, Paris
Sorbonne Université
France, Paris
Hôpital Européen Georges-pompidou
Le-Goff, Jérôme
France, Paris
Hôpital Européen Georges-pompidou
Si-Mohamed, Ali
France, Paris
Hôpital Européen Georges-pompidou
Bloch, Francis
France, Paris
Hôpital Européen Georges-pompidou
Mbopi-Kéou, François Xavier
United Kingdom, London
Eastman Dental Institute
United Kingdom, London
Central Public Health Laboratory
Becquart, Pierre
France, Paris
Sorbonne Université
Matta, Mathieu
France, Paris
Hôpital Européen Georges-pompidou
Prazuck, Thiérry
France, Villeneuve-saint-georges
Centre Hospitalier Intercommunal de Villeneuve-saint-georges
Petite, Jean Pierre
France, Paris
Hôpital Européen Georges-pompidou
Gutmann, Laurent
France, Paris
Hôpital Européen Georges-pompidou
Payan, Christopher
France, Angers
Chu Angers
Statistics
Citations: 19
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1016/S0168-8278(03)00119-3
ISSN:
01688278
Research Areas
Infectious Diseases
Participants Gender
Female